MAS1 Membrane Protein Introduction

Introduction of MAS1

MAS1, encoded by MAS1 gene, is a seven-transmembrane G-protein coupled receptor and preferentially couples to the G_q protein. It is a receptor for angiotensin-(1-7) and plays diverse roles in humans physiological activities by angiotensin-(1-7). Studies have shown that the ACE2-Ang-(1-7)-Mas pathway plays a crucial role in myocardial remodeling, glucose homeostasis, anti-proliferative, anti-vasodilatory and anti-metastatic. Moreover, ACE2-Ang-(1-7)-Mas axis can be regarded as a potential therapeutic target for cardiovascular disease, cancer, and diabetes.

Function of MAS1 Membrane Protein

The activated MAS1 by angiotensin-(1-7) can stimulate the activation of the phospholipase C signaling pathway thereby mediating multiple cellular responses. MAS1 functions as an antagonist of AGTR1 (angiotensin-2 type 1 receptor) despite it promotes AGTR1 expression. It can suppress the activation of AGTR1, resulting in vasodilatation and a decrease in blood pressure. Studies have shown that MAS1 may be involved in multiple processes including hypotension, smooth muscle relaxation, and cardioprotection by mediating the effects of angiotensin-(1-7). Besides, MAS1 as an antagonist of AGTR1 also plays a key role in the progression of tumors through controlling cell proliferation, survival, invasion, angiogenesis, and subsequent metastasis. Studies have shown that MAS1 acts as an inhibitory regulator of types of cancer and possible therapeutic target for malignant tumors, such as breast cancer, bladder cancer. In addition, MAS1 is associated with the inflammation responses via angiotensin-(1-7). The activated MAS1 via angiotensin-(1-7) can suppress inflammation responses by mediating leukocyte recruitment/activation. ACE2/Ang-(1-7)/Mas axis may be a promising therapeutic target for chronic inflammatory diseases.

Fig.1 Schematic representation for the role of ACE2-Ang-(1-7)-Mas receptor axis on renal tissue. (Silva, 2013)

Application of MAS1 Membrane Protein in Literature

1. Zhang Y., et al. Angiotensin-(1-7)-mediated Mas1 receptor/NF-κB-p65 signaling is involved in a cigarette smoke-induced chronic obstructive pulmonary disease mouse model. Environmental Toxicology. 2018, 33(1):5-15. PubMed ID: 28960804
   
   

   The article shows that angiotensin-(1-7) treatment suppresses lung inflammatory responses and lung fibrosis induced by cigarette smoke (CS) exposure.

2. Ghadhanfar E., et al. The role of ACE2, angiotensin-(1-7) and Mas1 receptor axis in glucocorticoid-induced intrauterine growth restriction. Reproductive Biology & Endocrinology. 2017, 15(1):97. PubMed ID: 29321064
   
   

   The study indicates that a reduced expression of ACE2 and Ang-(1-7) in the placenta by dexamethasone treatment may be responsible for intrauterine growth restriction (IUGR) and consequent disease programming later in life.

3. Lin S., et al. Role of the ACE2-Ang-(1-7)-Mas axis in blood pressure regulation and its potential as an antihypertensive in functional foods (Review). Molecular Medicine Reports, 2017, 16(4):4403-4412. PubMed ID: 28791402
   
   

   In this review, authors summarize recent findings regarding the physiological and biological roles of the ACE2-Ang-(1-7)-Mas axis in the cardiovascular system and discuss ACE2-Ang-(1-7)-Mas axis potential as an antihypertensive in functional foods.

4. Wang J., et al. The ACE2-Ang (1-7)-Mas receptor axis attenuates cardiac remodeling and fibrosis in post-myocardial infarction. Molecular Medicine Reports, 2017, 16(2):1973-1981. PubMed ID: 28656296
   
   

   The findings reveal that ACE2-Ang-(1-7)-MasR axis may play a protective role in the development of myocardial remodeling, suggesting ACE2-Ang-(1-7)-MasR axis can be regarded as a new target for drug development of cardiac fibrosis.

5. Assis A.D., et al. Pattern of Mas expression in acute and post-acute stage of nerve injury in mice. Peptides, 2017, 96:15-19. PubMed ID: 28870798
   
   

   The study indicates that Ang-(1-7)/Mas axis activity is differentially modulated in the acute and post-acute stages of nerve injury in mice model.

MAS1 Preparation Options

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Reference

1. Silva A S E, et al. (2013). ACE2, angiotensin-(1-7) and Mas receptor axis in inflammation and fibrosis. British Journal of Pharmacology, 169(3), 477-92.

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