Introduction of MCHR1
Melanin concentrating hormone receptor 1(MCHR1), also referred to MCH1, is a protein belonging to the G protein-coupled receptor family 1 encoded by MCHR1 gene. Melanin-concentrating hormone (MCH), a cyclic neuropeptide expressed predominantly in the lateral hypothalamus, plays an important role in the control of feeding behavior and energy homeostasis. Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide that plays an important role in feeding behavior. It activates two G-protein-coupled receptors, MCHR1 and MCHR2. As one of the melanin-concentrating hormone receptors, MCHR1 proteins are found in all mammals. The encoded protein is an integral plasma membrane protein which binds melanin-concentrating hormone.
|Basic Information of MCHR1|
|Protein Name||Melanin concentrating hormone receptor 1|
|Aliases||SLC1, GPR24, MCH1R, SLC-1, MCH-1R|
|Organism||Homo sapiens (Human)|
Function of MCHR1 Membrane Protein
It has been recognized that MCHR1 has a variety of functions such as the regulation of appetite, and in stress, anxiety and depression. MCHR1 can stimulate intracellular calcium flux, and inhibit cAMP accumulation and might be related to the neuronal regulation of food consumption. Through transfected with MCHR1 in mammalian cells, MCH is capable to activate multiple signaling pathways such as calcium mobilization, extracellular signal-regulated kinase activation, and inhibition of cyclic AMP generation through Gi/o- and Gq-coupled pathways. As an important regulator of feeding, this protein is selectively present in neuronal primary cilia in distinct regions of the mouse brain. The molecular mechanism of MCH1 receptor blockade by these antagonists was examined. MCHR1 antagonists have an influence on not only food intake, but also energy expenditure. A new class of potent MCH1 receptor antagonists like AZD1979 and 8-methylquinoline scaffold are considered as anti-obesity agents and bring promise for the treatment of human obesity.
Fig.1 Structure of MCHR1 membrane protein
Application of MCHR1 Membrane Protein in Literature
This article reports that MCH progressively has elicited cilia shortening without exclusion of fluorescence-positive material from the tip in live-cell imaging experiments and short cilia phenotypes have been associated with various metabolic disorders. All these findings may contribute to better understanding of how the cytoskeleton take part in the GPCR ligand-triggered cilia shortening with cell mechanical properties.
This article suggests that disruptions of MCH-1R signaling may be a useful pharmacological tool to inhibit the form of overeating behavior.
This paper shows that thienopyrimidinone MCHR1 antagonists trigger the hepatobiliary injury via a CYP-mediated bioactivation pathway.
This article indicates that MCH signaling might be associated with the ability of the food restriction (FR) to increase amphetamine-induced the conditioned place preference (CPP).
It is the first study which demonstrates that a slowly dissociating negative allosteric modulator of the MCH1 receptor inhibits the numerous signaling pathways of this receptor.
MCHR1 Preparation Options
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