Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
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HighlightsMelatonin receptors (MTNRs) are a group of high-affinity Gi/G0 protein-coupled receptors, which bind the hormone melatonin to regulate a wide variety of physiological processes. Three types of melatonin receptors have been cloned, including MTNR1A, MTNR1B, and MTNR1C. In humans and other mammals, MTNR1A and MTNR1B are present, however, MTNR1C has been identified in amphibia and birds. MTNR1C seems to be the hamster homolog of human quinone reductase 2 and is therefore not considered within the GPCRs. MTNR1A and MTNR1B are widely distributed in the brain (especially in the suprachiasmatic nucleus) and in the retina with high concentrations, while these receptors are detected in the kidney, heart, lung and liver with lower levels. MTNR1A modulates the circadian, neuronal firing, arterial vasocon-striction, cell proliferation in cancer cells, and reproductive and metabolic functions. MTNR1B is mainly expressed in the retina, suggesting the effect on the circadian rhythms. Furthermore, activation of MTNR1B inhibits dopamine release in retina, induces vasodilation and inhibition of leukocyte rolling in arterial beds, enhances immune responses, regulates proliferation and differentiation of osteoblasts and involves in the pathogenesis of type 2 diabetes.
Here show partial members of MTNRs, including MTNR1A and MTNR1B. There are a lot of agonists and antagonists for MTNR1A and MTNR1B have been identified, which can enhance or reduce the melatonin-mediated responses to affect the physiologic processes. Further studies about the MTNRs mediated specific functional responses in target tissues are beneficial for the design and development of novel therapeutic agent.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
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