Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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The nanodiscs is a non-covalent structure of lipid bilayer and membrane scaffold protein (MSP). MSPs are genetically engineered proteins, which derived from human apolipoprotein A-1 to shield the hydrophobic core of the lipids from the aqueous phase. The size of the nanodiscs was controlled by the length of the MSPs. The diameter of nanodiscs is typically in the order of ~10 nm, but the generation of specific MSP variants allows the formation of smaller (6-7 nm) and larger (16-17 nm) nanodiscs. Lipid-bilayer nanodiscs are the most powerful tool in solubilizing/incorporating membrane proteins in a cell membrane-like environment. This solubilization/incorporation system represents a very suitable option if you need to keep the folded conformation, intact function, and oligomerization of your target proteins all in their native forms.
In nanodiscs assembly, we will first solubilize your membrane proteins using detergents and purify them in a micellar solution. Since different detergents and detergent mixtures may affect the stability, structure, function, and activity of a membrane protein very differently. We can also use our detergent screening platform to find the most suitable detergent or detergent mixture for your membrane proteins. After the solubilization and purification, we will add lipids and the membrane scaffolding protein (MSP) to the micellar solution of membrane proteins followed by removing the detergents via hydrophobic beads binding or dialysis.
Nanodiscs are soluble nanoscale phospholipid bilayers that can self-assemble integral membrane proteins for biophysical, enzymatic, or structural investigations.
Creative Biolabs has been dedicated to providing first-class membrane protein production service using a variety of strategies. Based on our leading-edge platform, we have successfully produced, purified, stabilized, and characterized many challenging membrane protein targets. Nanodiscs are almost the perfect tool for solubilizing, reconstituting, and incorporating membrane proteins in a cell membrane-like environment. At Creative Biolabs, we guarantee our clients the most qualified and tailored service to satisfy each specific demand. Besides, you can also choose our services in solubilization/reconstitution of membrane proteins in liposomes, micelles, and amphipols. Please feel free to inquire us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
