Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe metabotropic glutamate receptors (mGluRs) belong to the group C family of G-protein-coupled receptors and are a type of glutamate receptors activated through an indirect metabotropic process. mGluRs have seven transmembrane domains that span the cell membrane just like other metabotropic receptors. mGluRs activate biochemical cascades that results in the modification of other proteins, such as ion channels. This may lead to changes in the synapse's excitability, such as presynaptic inhibition of neurotransmission, or modulation and even induction of postsynaptic responses.
Like other glutamate receptors, mGluRs bind to glutamate which is an amino acid that acts as an excitatory neurotransmitter. The mGluRs can be found in presynaptic and postsynaptic neurons in synapses of the cerebellum, cerebral cortex, hippocampus, and other parts of the brain and surrounding peripheral tissues and perform various functions in the central and peripheral nervous systems. They are involved in memory, learning, anxiety, and the perception of pain. The broad distribution of mGluR proteins suggests that these neuromodulatory receptors have the ability to participate in multiple functions of the central nervous system (CNS) and may represent ideal targets for therapeutic intervention in various CNS disorders.
Here show eight different types of mGluRs including GRM1 to GRM8 (mGluR1 to mGluR8), which are divided into groups I, II, and IIIbased on their structure and physiological activity. The mGluRs are further divided into subtypes, such as mGluR7a and mGluR7b.
Aided by cutting-edge MemDX™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell lines.
Meanwhile, our MemDX™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
