Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe d-block or transition metal ions manganese (Mn), iron (Fe), cobalt (Co), nickel (Ni), copper (Cu), zinc (Zn), and to a more specialized degree, molybdenum (Mo), tungsten (W) and vanadium (V), have been shown to play essential roles in many biological processes. They can act as structural components of bimolecular, as signaling molecules, as catalytic cofactors in reversible reactions, and so on. The transport of important metals and nutrient substances across tight membrane barriers, such as the blood-brain barrier, is mediated by certain particular mechanisms. Specific transporters carry metals on the apical surface, export them to the basolateral surface, and participate in their intracellular distribution. Transporters for each of the major metal have been identified, calcium (Ca), iron and zinc. Additionally, these transporters can also mediate non-essential metal transports to pass through the tight membrane barrier. For example, the iron transporter in the intestine, divalent metal transporter 1(DMT1), mediates the uptake of cadmium (Cd) and lead (Pb).
Here show the part of metal transporters in humans. The expression of genes encoding plasma membrane-bound transporters allowing for the high-affinity uptake of special metal ions into the cytosol is typically constitutive or “on” under unstressed homeostatic conditions. The levels of crucial metals are strictly regulated by transporters. When the dietary degree of these metals is low, levels of the corresponding transporters rise in intestines, after which there is a potentially rising for the transport of toxic metals.
Depending on cutting-edge Magic™ membrane protein production platform, Creative Biolabs would like to provide the preparation of these protein products in required formats by utilizing different strategies, for instance, detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
At the same time, our classical Magic™ membrane protein antibody discovery platform can assist to discover antibodies against these membrane proteins, even fully humanized antibodies, via many different approaches such as hybridoma technology, phage display technology, etc. Besides, we also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more details.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
