Close

Metalloreductase Family

Metalloreductases are proteins that mediate metal metabolism. They are also known as members of the human 6-transmembrane epithelial antigen of prostate (STEAP) family, which is composed of four members: STEAP1, STEAP2, STEAP3, and STEAP4. All members of this family share common features in their structure and act as metalloreductases in human, except for STEAP1. Overall, these proteins are involved in a wide range of physiological processes, such as the molecular trafficking in the endocytic and exocytic pathways, and control of cell proliferation and apoptosis. STEAPs, especially STEAP1 and STEAP2, are found to be overexpressed in several human cancers (e.g., prostate, bladder, kidney, and liver). Moreover, their localization in the cell membrane and the role of facilitating the proliferation and invasion of cancer cells, indicating that these proteins can be regarded as potential disease biomarkers and immunotherapeutic targets against cancers. However, the mechanisms remain largely elusive and are required to be elucidated. Further researches exploring the expression, regulation, and role of STEAP proteins in cancer pathophysiology, diagnosis, and therapeutic approaches are needed to be conducted in the future.

Here, we briefly introduce our current knowledge about these two members of the STEAP family, STEAP1 and STEAP2, focusing on the tissue distribution, roles in human physiology and disease, as well as their potential as immunotherapeutic agents in cancer therapy.

Human Metalloreductase Family Members
STEAP1 STEAP2

The study of membrane proteins is challenging due to the difficulties to extract them from their natural environment and subsequently maintain them in stable, water-soluble formats. With a particular focus on this field, Creative Biolabs now introduces our powerful Magic™ Membrane Protein platform to help prepare your target membrane proteins in different functional formats. We can use traditionally-used and newly-developed detergents selected from our detergent screening platform. Moreover, alternative membrane mimetics and tools such as proteoliposomes, nanodiscs, lipoparticles, and polymers can also be provided here. These new techniques provide more structurally and functionally intact membrane proteins for in vitro studies.

Magic™ membrane protein production platform – Creative Biolabs

Meanwhile, we introduce our Magic™ membrane protein antibody discovery platform that enables the development of antibodies against these protein antigens. Our state-of-the-art production units and highly qualified personnel guarantee that we can deliver maximum quality and flexibility in all stages of our services. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.

Online Inquiry

Verification code
Click image to refresh the verification code.

CONTACT US

45-1 Ramsey Road, Shirley, NY 11967, USA
Call us at:
USA: 1-631-381-2994
Europe: 44-207-097-1828
Fax: 1-631-207-8356
Email:
Our customer service representatives are available 24 hours a day, 7 days a week. Contact Us