Introduction of MLNR
Motilin receptor (MLNR), a 22 amino acid peptide hormone, is encoded by the motilin receptor gene. The protein belongs to the G-protein coupled receptor 1 family, which is expressed throughout the gastrointestinal (GI) tract. This member is a multi-pass transmembrane protein and is an important therapeutic target for the treatment of hypomotility disorders. Motilin receptor mRNA is found significantly high-expressed in the duodenum and at their highest concentrations in the nerves of the antral wall of the stomach and are also found at significant levels throughout the smooth muscle of the upper gastrointestinal (GI) tract and in the enteric nervous system.
|Basic Information of MLNR|
|Protein Name||Motilin receptor|
|Aliases||G-protein coupled receptor 38|
|Organism||Homo sapiens (Human)|
Function of MLNR Membrane Protein
Motilin Receptors are Gq/11-protein-coupled receptors that mediate progastrokinetic effects. Motilin receptors promote gastric emptying after food intake and increase smooth muscle contraction in the GI tract. Motilin receptors have not been identified in rodents, but have been cloned in rabbits and humans. The phase III contractions are induced by motilin as a hunger signal and occur as part of the migrating motor complex (MMC), a contractility pattern of the gastrointestinal tract during fasting. However, the mechanism involved in this association between subjective hunger feelings and gastrointestinal motility during the MMC and its ability to stimulate food intake are largely unknown.
Fig.1 Structure of MLNR membrane protein.
Application of MLNR Membrane Protein in Literature
This article reports that motilin receptor stimulation during the fasting state does not affect total caloric intake nor does endogenous motilin stimulate meal requests after breakfast in the current study population.
This article reveals that reduced expression of MLNR is possibly related to that vascular permeability in the hind plantar skin of rats decreases following lumbar sympathectomy.
This article uncovers five non-orthosteric sites on the MLNR which are potential for the treatment of inflammatory and neurological diseases, through applying the fragment-based mapping algorithm, FTMap, on the conformations of MLNR.
This article assesses the safety, tolerability, pharmacokinetics, and pharmacodynamic effects on proximal and distal gastrointestinal (GI) motility of single oral doses of a Motilin Receptor Agonist DS-3801b in healthy subjects.
Dependent on structural information and on animal studies, this article focuses on the study of motilin and demonstrates the need to avoid overreliance on artificial systems.
MLNR Preparation Options
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