Monoclonal Canine (Dog) Antibody Production

As a recognized leader in the field of phage display and antibody engineering, Creative Biolabs is specialized in producing monoclonal rabbit, chicken, llama, dog, monkey, mouse and human antibodies utilizing phage display antibody library technology. Particularly, we are proud to be the first and the only company to provide monoclonal canine antibody generation services.

Based on our extensive experience in phage display library construction and screening, scientists of Creative Biolabs have created several immunized canine antibody libraries, from which we have successfully isolated a number of high affinity antibodies using panning techniques. With this strategy, we can generate custom monoclonal canine antibodies that have the potential for use in a wide range of biomedical applications including the treatment of malignant, infectious, inflammatory and autoimmune diseases in dogs, paving the way for exploration of such applications in canine medicine.

As for antigens that are not suitable for immunization, we are also pleased to make a custom synthetic canine antibody library for you based on our full understanding of the canine antibody repertoires. We can take the major framework sequence of the light chain and heavy chain of canine antibody repertoires and then create mutations/variations in all 6 CDR regions (or 2 CDR3 regions). Combined with various mutation strategies, we can produce canine antibodies against any antigens, including those that are toxic and of no immune response in animals.

Besides developing monoclonal canine antibodies, Creative Biolabs has also established a platform for monoclonal antibody caninization, murinization and humanization services.

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