We happily announce that now Creative Biolabs can offer the unique monoclonal human antibody production service with ethics approval. Taking advantage of the advanced phage display technology, our scientists can generate high-quality human antibody libraries and isolate antibodies with high specificity and affinity to the interested targets.
The human antibody, especially the target-specific monoclonal antibody, is one of the most desirable and important materials in the current immunotherapeutic area. For cancer treatment and other antibody drug development, human antibodies are absolutely one of the best choices due to the capacity to minimize the potential risk of immunogenicity caused by non-human antibodies. Nonetheless, it is obviously unacceptable to immunize human with interested antigens to produce antibody due to the serious ethical and moral issues. Fortunately, thanks to the understanding of the human genome and the development of biotechnologies, this issue has been legally addressed by phage display technology. Over the past twenty years, phage display has been the most widely used system for de novo production of human antibodies.
As an available source of fully human antibody, human immunized antibody library is generally constructed from the donative peripheral blood of patients with infectious diseases or cancer, or subjects who have recently been vaccinated with approved vaccines. Although the antigen-specific B cells are rare in human peripheral blood, this approach is still a good way to recover antibodies from a specific known immunogen (e.g. anthrax toxin) or infectious agent (e.g. SARS virus). Antibodies in this library are significantly enriched for the specific target and undergo a natural maturation process, so they are expected to have higher specificity and affinity to the targets.
Creative Biolabs, one well-recognized expert in antibody realm, has rich experience in the production of human antibodies via our advanced phage display technology. Utilizing samples containing antigen-specific B cells, our scientists are able to offer the customized service of generating and screening the human immunized antibody libraries to obtain the desired fully human antibodies with high specificity and affinity. Moreover, Creative Biolabs provides our unique Native™ Antibody Discovery Platform, which is based on antigen-specific B lymphocytes cytometry technology, for Native™ Human Antibody Discovery.
Creative Biolabs has years of experience in antibody development. We have supplied thousands of different antibodies for our global customers. Our experienced scientists will provide the best service and generate high-quality monoclonal human antibodies to benefit our clients’ research and project.