Diadigom of immuno reactions after therapeutic
administration. (Lollini et al. 2006)
Creative Biolabs is a leading service provider of monoclonal antibodies from various species. We are proud to induce the porcine (pig) monoclonal antibody production service to our customers all over the world.
Porcine belongs to the order Artiodactyla. It expresses IgM, IgD, IgG, IgE, and IgA antibodies just like mice and humans, but with a larger IgG subclass. VH genes expressed by porcine belong to VH3 family, in which >80% or the pre-immune repertoire comes from five genes. The junctional diversity of porcine is more important compared to the repertoire formation in humans and mice because they primarily use two DH segments and one JH. Because of the proportional light chain usage, it is distinct from the predominant kappa chain usage of lab rodents and the predominant lambda chain usage in other ungulates.
Creative Biolabs has developed a superior phage display platform, which guarantees the production of high-quality antibodies. The B cells from the immunized pig will be collected, and the antibody RNA will be extracted. With our extensive experience in phage display library construction, a porcine immune library with a diversity up to 1010 will be built. The key step of selection of a quality binder is the biopanning. Several methods have been incorporated, such as solid phase screening, solution-sorting screening, and cell-based screening. The antibody candidates will be enriched, amplified and verified. In addition, our Magic™ Antibody Repertoire Analysis service will provide in-depth knowledge of the resulted sub-library.
Besides porcine/swine monoclonal antibody production service, Creative Biolabs also provides monoclonal antibodies from various types of animals, including but not limited to:
Creative Biolabs has dedicated to phage display antibody production for over a decade. We have a proven record of providing custom monoclonal porcine (pig)antibody production service to our customers. Combined with our phage display platform and the antibody engineering services, our scientists could offer one-stop custom antibody development tailored to the unique requirements of our customers.