Creative Biolabs offers custom rat monoclonal antibody production service by our advanced phage display technology. Our experts of antibody library construction and screening are confident in tailoring the most specific monoclonal antibody production service to meet our customers’ research objective.
Rats, as just the second popular rodent used in the laboratory, have contributed to a variety of academic studies that widely related to genetics, therapeutics, pathology, psychology and so on. The use of experimental rats can be traced back to 18th century when a group of domestic albino brown rats was firstly established for a series of purely scientific purposes. Since the publication of fully sequenced rat genome, this species has become one of the most important and widely used experimental animals, just behind its rodent brother, mouse. Actually, it has been utilized in almost every aspect of biomedical and behavioral research. Similar with other rodents that commonly used in the laboratory, rats also indicate closer gene relationship with the human and share several advantages such as lower feeding cost and ease of maintenance and handling, which enable this species to be treated as the preeminent mammalian model organism in numerous fields.
Undoubtedly, rats are the ideal source for antibody discovery and the rat monoclonal antibodies may offer several advantages over mice. Analogously, rats also produce the IgA, IgD, IgE, IgG and IgM antibody isotypes and recognize a broad range of human proteins as antigens. While the mainly different advantages between mice and rats are realized that rats can induce the immune response to mouse antigens and they are larger murine which means greater lymphocyte yield and reduced antigen requirement. In addition, the rat antibodies are found do not have the cross reaction in immune-detection of antigens out of a mouse background, which shown as a strong point in some sandwich assays. Therefore, rat monoclonal antibodies are the ideal alternative or complement for various researches to acquire wider repertoires and isolate antibodies against novel targets with higher affinity.
In general, hybridoma is a difficult method to develop monoclonal rat antibody due to the lack of stable fusion partner, while in Creative Biolabs, our scientists can provide the advanced phage display technology to obtain rat monoclonal antibodies through our one-stop service. From the routine immunization to the generation and screening of immunized rat antibody libraries, a number of rat monoclonal antibodies with high affinity and specificity can be selected by our mature phage display technology and biopanning strategy. Moreover, to meet the special demand of naturally paired antibody, Creative Biolabs can also provide our unique Native™ Antibody Discovery Platform, which based on antigen-specific B lymphocytes cytometry technology, to substitute phage display platform for Native™ Rat Antibody Discovery.
As a well-recognized antibody related services provider, Creative Biolabs has accomplished thousands of antibody services for our global clients. With years of experience, our scientists are confident in producing the best monoclonal antibodies with high affinity and specificity to satisfy our customers’ requirement.