ImmunoArrayᵀᴹ Antiphospholipid Syndrome (APS) and Neutrophil Extracellular Traps (NETs) Related Citrullinated Protein Autoantibody Detection Service (CAT#: NA-0726-FY18)

Developed by Creative Biolabs, the APS and NETs-Related Citrullinated Protein Autoantibody Detection Service utilizes an advanced, high-sensitivity protein microarray platform to profile autoantibody signatures against 120 literature-backed citrullinated antigens. By immobilizing post-translationally modified citrullinated proteins onto a nitrocellulose membrane surface, this high-throughput, low-sample-rate service allows researchers to precisely evaluate autoimmune signatures linked to APS, NETosis, and advanced systemic diseases like RA. It serves as a powerful translational medicine tool, aiding in the discovery of clinically valuable antibody biomarkers, deciphering disease pathogenesis, and establishing multi-parametric models for early diagnostics, prognosis, and treatment monitoring.

Specifications
Size16-sample format per slide; features advanced multiplexing capable of profiling>120 targets per well (encompassing the 120 specific disease-related antigens).
Throughput LevelHigh-throughput (processes 16 samples per slide simultaneously, with support for parallel operations across multiple slides).
Protein CountUp to 120 types of citrullinated proteins.
Proteome CoverageFocused panel consisting of 120 citrullinated proteins thoroughly reviewed in literature and established as being explicitly associated with systemic autoimmune diseases, specifically targeting Antiphospholipid Syndrome (APS), Rheumatoid Arthritis (RA), and Systemic Lupus Erythematosus (SLE).
Arraying TechnologyHigh-sensitivity antigen microarray technology (protein microarray) where post-translationally modified citrullinated proteins are orderly immobilized as ligands onto the nitrocellulose membrane surface of glass slides; molecular interactions are captured via fluorescent labeling and quantified using a fluorescence scanner.
FeaturesHigh Multiplexing: Screens>120 autoantibodies simultaneously in a single well, far outperforming traditional single-target ELISA methods. Targeted Modification: Focuses on citrullinated proteins immobilized on a nitrocellulose membrane surface, crucial for identifying anti-citrullinated protein antibodies (ACPAs). Ultra-low Sample Volume: Requires only 5 μL of serum or other body fluids, heavily conserving clinical specimens. High Flexibility: Dynamically combines diverse antigen matrices (proteins, peptides, nucleic acids) to detect distinct antibody types and subclasses. High Sensitivity & Wide Dynamic Range: Yields a broad signal dynamic range spanning from 1 to 65000. Cost-Effective: Delivers massive profiling capabilities at less than 1/10 of the cost of traditional ELISA kits. Semi-Quantitative: Supports relative quantification derived from established standard curves.
Application FieldsAPS, NETs & Citrullinated Target Autoimmunity: High-efficiency screening and biomarker profiling for Antiphospholipid Syndrome (APS), Rheumatoid Arthritis (RA, where citrullination plays a key role), Systemic Lupus Erythematosus (SLE), diabetes, MCTD, Sjögren's syndrome, scleroderma, polymyositis, dermatomyositis, etc. Translational & Clinical Research: Large-scale immune profiling across allergic diseases, infectious diseases, neurological impairments/brain nerve disorders, oncology (cancer biomarkers), vaccine R&D/post-vaccination monitoring (e.g., SARS-CoV-2, RSV, influenza), organ transplantation evaluation, drug screening, and clinical trials.
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For Research Use Only | Not For Clinical Use

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