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ImmunoArrayᵀᴹ Autoimmune Infertility-Associated Autoantibody Detection Service/Antigen Microarray (CAT#: NA-0726-FY5)
Autoimmune Infertility-Associated Autoantibody Detection Service is a high-sensitivity, multiplexed antigen microarray platform engineered to uncover the immunological drivers of unexplained infertility and recurrent pregnancy loss. By displaying 25 carefully selected reproductive and systemic autoantigens in their native three-dimensional conformations across a 3D microchip surface, the array screens for an expansive fingerprint of fertility-disrupting antibodies from a mere 5 μL sample. Capable of simultaneous dual-isotype detection (IgG/IgM/IgA) across 16 parallel samples per slide, the platform bypasses the throughput and sample limits of traditional ELISAs at a fraction of the cost. Armed with an extensive 1-65000 dynamic range and integrated internal Ig controls, it serves as a powerful engine for mapping reproductive immunopathology, identifying novel clinical biomarkers, and guiding targeted immunomodulatory interventions to improve fertility outcomes.
| Specifications | |
|---|---|
| Size | Standard microchip substrate layout (Standard glass slide format) |
| Throughput Level | High-throughput parallel processing; 16 samples can be processed simultaneously per individual slide |
| Protein Count | Features 25 reproductive and autoimmune-associated antigens (selected via comprehensive review of peer-reviewed literature) |
| Proteome Coverage | Target-specific disease coverage (Capable of multiplexed profiling of over 120 autoantibodies per reaction well) |
| Full-Length Protein Ratio | High conformational fidelity (Pure antigens are coated onto a 3D matrix to optimally retain their native three-dimensional structures) |
| Expression System | High-quality purified antigen production lines engineered to protect native biological epitopes |
| Purification Method | Advanced affinity and high-purity antigen isolation |
| Arraying Technology | Precise automated deposition onto a proprietary three-dimensional (3D) microchip surface |
| Quality Control | Integrated internal Ig and anti-Ig control pairs within every array for rigorous data normalization and quantification |
| Features | High Multiplexing & Ultra-Low Volume: Replaces standard single-plex ELISA formats by evaluating more than 120 distinct autoantibodies simultaneously in a single well, utilizing a micro-volume sample input of just 5 uL of serum or alternative biofluids. Simultaneous Dual-Isotype Screening: Incorporates dual-color fluorescence-conjugated secondary antibodies to independently read two distinct antibody classes (e.g., IgG/IgM or IgA) on the same array surface, significantly saving precious clinical samples. Broad Linear Dynamic Range: Delivers an exceptional signal detection spectrum ranging from 1 to 65000 Relative Fluorescence Units (RFU), enabling sensitive relative quantification and semi-quantitative profiling via robust standard curves. Excellent Cross-Platform Flexibility & Affordability: Allows tailored screening by immobilizing diverse biomolecules (proteins, peptides, nucleic acids) across multiple antibody subtypes, reducing experimental cost barriers to less than 1/10 the price of conventional ELISA kits. |
| Application Fields | Unexplained Infertility Profiling: Uncovering cryptic immunopathological mechanisms in couples suffering from unexplained or idiopathic infertility by identifying underlying tissue-specific or systemic autoimmune activity. Reproductive Failure Diagnostics: Screening for critical autoantibodies linked to recurrent pregnancy loss (RPL), early-stage embryo implantation failure, and placental microvascular pathologies (e.g., Anti-Ovarian [AOA], Anti-Sperm [ASA], Antiphospholipid [aPL], and Antinuclear [ANA] antibodies). Premature Ovarian Insufficiency (POI) Studies: Investigating autoimmune-mediated destruction of ovarian tissues and eggs, which can cause early menopause or rapid diminished ovarian reserve. Endocrine & Systemic Cross-Talk Research: Mapping the intersections where autoantibodies disrupt the Hypothalamic-Pituitary-Gonadal (HPG) axis, thyroid hormones, or trigger systemic inflammation that undermines reproductive organ function. Clinical Stratification & Immunotherapy Monitoring: Providing predictive multi-parameter biomarkers to guide clinical trial choices and monitor patient responses to reproductive immunotherapies (e.g., glucocorticoids, immunosuppressants). |
DatasheetFor Research Use Only | Not For Clinical Use
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