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ImmunoArrayᵀᴹ Ganglioside and Phospholipid Antigen Microarray Service (CAT#: NA-0726-FY11)
A highly specialized, high-sensitivity antigen microarray service explicitly engineered for profiling autoantibodies against the largest collection of ganglioside and phospholipid antigens. Recognizing the challenges posed by the high hydrophobicity of these non-protein targets, the platform uses optimized surface chemistry on nitrocellulose membranes to perfectly lock their native 3D conformations. Requiring only 5 μl of serum or body fluid, this cost-effective, high-multiplex service provides robust semi-quantitative profiling to accelerate biomarker discovery, clinical diagnostics, and translational research in neuro-autoimmunity and Antiphospholipid Syndrome (APS).
| Specifications | |
|---|---|
| Throughput Level | High throughput (Capable of processing 16 samples simultaneously per slide, with multiple slides operable in parallel) |
| Protein Count | Contains 21 non-protein antigens (gangliosides and phospholipids)/Capable of detecting more than 120 autoantibodies per well platform-wide |
| Proteome Coverage | Specifically targets the largest collection of ganglioside and phospholipid types associated with neurological autoimmune conditions and Antiphospholipid Syndrome (APS). |
| Purification Method | Utilizes highly specialized processing and treatment methods tailored for highly hydrophobic non-protein antigens to maintain their structures. |
| Arraying Technology | Specialized microarray technology where antigens are spotted on a nitrocellulose membrane substrate using a unique deposition method that preserves their native, three-dimensional conformational structures despite their high hydrophobicity. |
| Features | Features high technical reproducibility: each antigen is printed at three distinct concentrations, with two technical replicates per concentration (totaling 6 spots per antigen). Offers a wide dynamic range of 1 to 65000 and semi-quantitative analysis based on standard curves. |
| Application Fields | 1. Neurological & Autoimmune Disorders: Guillain-Barré Syndrome, Myelitis, Brown-Séquard Syndrome, Miller-Fisher Syndrome, Antiphospholipid Syndrome (APS), and other nervous system disorders. 2. Disease Warning & Diagnosis: Systemic and organ-specific autoimmune diseases (e.g., SLE, Rheumatoid Arthritis, Diabetes, MCTD, Sjögren's syndrome, Scleroderma, Polymyositis, Dermatomyositis), Allergies, and Cancers. 3. Treatment & Clinical Research: Selecting therapeutic methods, evaluating treatment efficacy, prognosis analysis, drug screening, clinical trials, and organ transplantation outcome assessment. 4. Vaccine Safety Monitoring: Viral vaccine development and post-vaccination monitoring for unexpected autoimmune adverse events (e.g., SARS-CoV-2, other coronavirus strains, Influenza, and RSV). 5. Biomarker Discovery: Constructing multi-parametric disease models and discovering clinically valuable antibody markers. |
DatasheetFor Research Use Only | Not For Clinical Use
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