ImmunoArrayᵀᴹ Glycosaminoglycan (GAG) Microarray (CAT#: NA-0726-FY37)

The Glycosaminoglycan (GAG) Microarray is a high-sensitivity carbohydrate-binding matrix engineered to systematically map interactions with complex mucopolysaccharide structures. Displaying 47 structurally distinct GAG chains-spanning hyaluronic acid, heparin, heparan, chondroitin, dermatan, and keratan sulfate lines-immobilized across an 8- or 16-subarray configuration, this high-throughput tool resolves target binding specificities from minimal sample volumes. Serving as a essential tool for functional glycomics, this platform enables translational medicine researchers to decode how diverse disaccharide sequences and sulfation codes dictate extracellular matrix scaffolding, tumor cell progression, microbial engagement, and amyloid plaque deposition pathways.

Specifications
SizeMulti-array slide format featuring 8 or 16 identical sub-arrays per chip, enabling parallel multi-sample profiling. It accommodates 47 structurally distinct GAG targets plus controls.
Throughput LevelHigh-throughput (enables the simultaneous analysis of 8 to 16 samples on a single chip, delivering rapid and reliable ligand-binding results).
Arraying TechnologyMultiplex glycan microarray technology where 47 distinct GAG structures are orderly printed onto the sub-arrays of a solid slide surface; molecular binding interactions (such as the human CD44-hFc binding model resolved via anti-human IgG-Cy3 secondary chemistry) are captured and measured using a microarray scanner at a 532 nm wavelength.
Quality ControlIntegrated positive controls are embedded within each sub-array layout to demonstrate expected target-ligand binding signals (such as validating the signature CD44 interaction with Hyaluronic Acid [GAG7]), ensuring accurate printing alignment and overall assay validity.
Features47 Diverse GAG Architectures: Curated library covering variations in chain length, disaccharide sequence, and precise sulfation positions. Unmatched Sensitivity & Specificity: Specially optimized to identify subtle variations in complex mucopolysaccharide binding preferences. Flexible 8 or 16 Sub-Array Format: Engineered with 16 or 8 identical testing blocks per slide to facilitate streamlined multi-variable comparative screening. Ultra-low Sample Volume: Employs a simplified, highly efficient micro-assay format requiring only minimal biological sample sizes. Customization & Service Support: Fully customizable (allowing users to select specific GAG structures for custom microarray formats) and available as a comprehensive analytical testing service.
Application FieldsBinding Specificity Evaluation: Assessing the precise carbohydrate-binding preferences of GAG-interacting host proteins (e.g., receptors like CD44) and target antibodies. Pathogen Host-Entry Research: Investigating complex structural interactions between defined cell-surface GAG chains and viruses or bacteria that hijack host mucopolysaccharides to establish infection or evade immunity. Biomedical Oncology & Neurodegeneration Studies: Analyzing altered GAG sulfation patterns tied to poor prognosis in breast, ovarian, colorectal, prostate, and gastric cancers; mapping how sulfated GAGs act as pathological chaperones to assist Amyloid-β (Aβ) aggregation in Alzheimer's disease, or how specific N-sulfated variants reduce it. Interactome & Cellular Profiling: Exploring binding activities with diverse biological targets including whole cells, cell lysates, serum, and vesicles.
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For Research Use Only | Not For Clinical Use

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