ImmunoArrayᵀᴹ Heparan Sulfate Glycan Microarray (CAT#: NA-0726-FY31)

The Heparan Sulfate Glycan Microarray is a high-sensitivity carbohydrate-binding matrix engineered to systematically map interactions with complex, unbranched glycosaminoglycans. Displaying 24 structurally distinct heparin and heparan sulfate configurations-varying precisely by chain length and sulfation degree-immobilized across an 8- or 16-subarray configuration, this high-throughput tool resolves target binding specificities from minimal sample volumes in just a few hours. Serving as a powerful tool for functional glycomics, this platform enables researchers to decode how linear carbohydrate sulfation codes dictate physiological homeostasis, extracellular matrix anchoring, lipid uptake, amyloid fibril formation, and microbial host-cell entry pathways.

Specifications
SizeMulti-array slide format featuring 8 or 16 identical sub-arrays per chip, allowing simultaneous multi-sample profiling. It accommodates 24 structurally defined heparan sulfate and heparin oligosaccharide targets plus controls.
Throughput LevelHigh-throughput (enables the parallel analysis of 8 to 16 samples on a single chip, delivering rapid results within a few hours).
Arraying TechnologyMultiplex glycan microarray technology where 24 distinct heparan sulfate structures are orderly printed onto the sub-arrays of the slide surface; molecular binding interactions (such as the Antithrombin III binding model resolved via primary and secondary antibodies) are captured and measured using a microarray scanner at a 532 nm wavelength.
Quality ControlIntegrated positive controls are embedded within each sub-array layout to validate expected target-ligand binding signals, ensuring printing alignment and overall assay validity.
Features24 Structurally Defined Targets: Contains a curated library of 24 distinct heparin and heparan sulfate glycan structures varying by length and sulfation levels. High Sensitivity & Specificity: Highly optimized to identify subtle variations in sulfation patterns and carbohydrate chain length. Flexible 8 or 16 Sub-Array Format: Designed with 16 or 8 identical testing zones per slide to facilitate parallel multi-sample screening. Ultra-low Sample Volume: Employs a simplified, highly efficient micro-assay format requiring only minimal biological sample sizes. Customization & Service Support: Fully customizable (allowing users to select specific structures for customized microarray formats) and available as a comprehensive analytical testing service.
Application FieldsBinding Specificity Evaluation: Assessing the precise binding preferences of heparan sulfate/heparin-interacting proteins (e.g., Antithrombin III) and target antibodies. Pathogen Host-Entry Research: Investigating complex structural interactions between defined carbohydrate chains and viruses or bacteria acting as host cell receptors/co-receptors. Interactome & Cellular Profiling: Exploring binding activities with diverse biological targets including whole cells, vectors, and vesicles. Biomedical Disease Mechanistic Studies: Investigating heparan sulfate proteoglycan (HSPG) dysregulation in cancer pathogenesis (angiogenesis, immune evasion, extracellular matrix remodeling) and amyloid diseases (Alzheimer's disease, Parkinson's disease, and TTR amyloidosis).
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