ImmunoArrayᵀᴹ Human Milk Oligosaccharides (HMO) Glycan Microarray (CAT#: NA-0726-FY33)

The Human Milk Oligosaccharides (HMO) Glycan Microarray is a high-sensitivity carbohydrate-binding matrix engineered to systematically map interactions with complex maternal milk sugars. Displaying 46 structurally distinct oligosaccharides-universally prevalent in human breast milk-immobilized across an 8- or 16-subarray configuration, this high-throughput tool resolves target binding specificities from minimal sample volumes in just a few hours. Serving as an essential tool for functional glycomics, this platform enables researchers to decode how distinct carbohydrate structures and fucosylated epitopes dictate infant gut mucosal immunity, homeostatic cell signaling, pathogen decoy defense, and anti-tumor mechanisms.

Specifications
SizeMulti-array slide format featuring 8 or 16 identical sub-arrays per chip, enabling parallel multi-sample profiling. It accommodates 46 structurally well-defined HMO structures plus positive controls.
Throughput LevelHigh-throughput (enables the simultaneous analysis of 8 to 16 samples on a single chip, yielding reliable ligand-binding profiles within just a few hours).
Arraying TechnologyMultiplex glycan microarray technology where 46 distinct HMO structures are orderly printed onto the sub-arrays of the slide surface; molecular binding interactions (such as the Aleuria aurantia lectin [AAL] binding model resolved via biotin-streptavidin-Cy3 chemistry) are captured and measured using a microarray scanner at a 532 nm wavelength.
Quality ControlIntegrated positive controls are embedded within each sub-array layout to demonstrate expected target-ligand binding signals, ensuring accurate printing alignment and overall assay validity.
Features46 Prevalent HMO Structures: Contains a curated library of 46 structurally defined oligosaccharides essential for mapping human breast milk glycan biology. High Sensitivity & Specificity: Specially optimized to identify subtle variations in oligosaccharide backbones, linkages, and maternal fucosylation variants. Flexible 8 or 16 Sub-Array Format: Designed with 16 or 8 identical testing blocks per slide to facilitate streamlined multi-variable comparative screening. Ultra-low Sample Volume: Employs a simplified, highly efficient micro-assay format requiring only minimal biological sample sizes. Customization & Service Support: Fully customizable (allowing users to select specific HMO structures for customized microarray formats) and available as a comprehensive analytical testing service.
Application FieldsBinding Specificity Evaluation: Assessing the precise binding preferences of HMO-interacting host proteins and targeted antibodies. Pathogen Inhibition Research: Investigating complex structural interactions between defined HMO chains and viruses or bacteria to study how maternal sugars act as anti-infective decoys/inhibitors. Developmental & Oncology Studies: Exploring binding activities with whole cells, cell lysates, serum, and vesicles to decipher how HMOs modulate infant gut microbiota (commensal bacteria growth), neurodevelopment, immune maturation, and tumor cell growth suppression. Biomarker Profiling: Utilizing specific HMO configurations as clinical biomarkers to evaluate infant digestive development, diarrhea incidence, and overall morbidity/disease risk.
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For Research Use Only | Not For Clinical Use

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