ImmunoArrayᵀᴹ Myasthenia Gravis-Related Autoantibody Detection Microarray Service (68-Antigen Array) (CAT#: NA-0726-FY14)

Developed by Creative Biolabs, the Myasthenia Gravis-Related Autoantibody Detection Service leverages an advanced, high-sensitivity protein microarray platform to profile autoantibodies against 68 carefully curated antigens. By preserving the native conformation of critical neuromuscular junction targets (such as AChR, MuSK, LRP4, and RYR) on a 3D surface, this service provides an efficient, low-sample-rate, and cost-effective solution for large-scale immune profiling. It serves as a powerful tool for discovering clinical antibody biomarkers, decoding disease pathogenesis, and establishing multi-parametric diagnostic and prognostic models for chronic neuromuscular autoimmune disorders.

Specifications
Size16-sample format per slide; features advanced multiplexing capable of profiling>120 targets per well (including 68 MG-specific/related antigens + internal controls).
Throughput LevelHigh-throughput (processes 16 samples per slide simultaneously, with support for parallel operations across multiple slides).
Protein Count68 types of high-quality purified antigens.
Proteome CoverageFocused array targeting 68 critical antigens highly correlated with Myasthenia Gravis (MG) and related neuromuscular disorders. Includes key neuromuscular junction targets such as Acetylcholine Receptor (AChR), MuSK, LRP4, and RYR (Ryanodine Receptor).
Arraying TechnologyHigh-sensitivity antigen microarray technology (protein microarray) where antigens are immobilized onto a three-dimensional (3D) coated surface; uses fluorescent secondary antibodies and fluorescence scanning to detect signal intensities.
Quality ControlEach array integrates internal Ig and anti-Ig control pairs to ensure reliable data normalization and relative quantification.
FeaturesHigh Multiplexing: Screens>120 autoantibodies per well (far exceeding traditional single-target ELISA methods). Ultra-low Sample Volume: Requires only 5 μL of serum or other body fluids to minimize sample consumption. Multi-Isotype Detection: Simultaneously detects two antibody types on a single array. High Sensitivity & Wide Dynamic Range: Signal intensity ranges from 1 to 65000. Cost-Effective: Priced at less than 1/10 of traditional ELISA kits. Semi-Quantitative: Enables relative quantification based on standard curves.
Application FieldsNeuromuscular & Autoimmune Diseases: Diagnosis, monitoring, subgroup classification, and pathogenesis research of Myasthenia Gravis (MG), Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA), diabetes, MCTD, Sjögren's syndrome, scleroderma, polymyositis, dermatomyositis, etc. Other Pathology Areas: Allergic diseases, infectious diseases, brain nerve disorders/neurological impairments, and cancer biomarker discovery. Translational & Clinical Research: Vaccine R&D and post-vaccination monitoring (e.g., SARS-CoV-2, RSV, influenza), organ transplantation evaluation, immunomodulatory therapy toxicity monitoring, drug screening, and clinical trials.
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