ImmunoArrayᵀᴹ N-Glycan Microarray (CAT#: NA-0726-FY30)

Developed as a specialized carbohydrate-binding matrix, the N-Glycan Microarray is an advanced high-throughput tool designed to systematically map glycan-protein interactions. Displaying 114 structurally distinct N-glycan variants (encompassing high-mannose, complex, and hybrid lines) across an 8- or 16-subarray configuration, this low-sample-rate platform captures precise carbohydrate-binding preferences within a few hours. Extensively cited in high-impact immunology and virology literature (e.g., HIV broadly neutralizing antibody research and SARS-CoV-2 variant profiling), this chip serves as an essential tool for decoding how post-translational glycan modifications dictate cellular signaling, immune escape, and malignant transformation. (Note: While the source text contains a brief typographical mention of O-glycans under its platform description, the product is functionally dedicated to N-glycan interactome profiling).

Specifications
SizeMulti-array slide format featuring 8 or 16 identical sub-arrays per chip, allowing simultaneous multi-sample profiling. It accommodates 114 distinct structural variants of N-glycans plus positive controls.
Throughput LevelHigh-throughput (enables the parallel analysis of 8 to 16 samples on a single chip, facilitating large-scale comparative screening with a rapid workflow).
Arraying TechnologyMultiplex glycan microarray technology where 114 specific N-glycan structural variations are orderly printed onto sub-arrays on a slide surface; molecular binding events (e.g., using biotinylated HHL lectin paired with Streptavidin-Cy3) are captured and resolved via a microarray scanner at a 532 nm wavelength.
Quality ControlIntegrated positive controls are embedded within each array layout to yield the expected binding signals, ensuring printing alignment, data normalization, and assay validity.
FeaturesHigh Sensitivity & Specificity: Highly optimized to identify distinct glycan-protein binding rules and subtle structural differences (e.g., distinguishing high-mannose vs. complex forms). Flexible Sub-Array Layout: Available in 8 or 16 identical sub-array formats per slide to accommodate varying multi-sample throughput needs. Ultra-low Sample Volume: Employs a highly efficient micro-assay format requiring only minimal biological or protein sample sizes. Customization & Service Support: Fully customizable to meet individual client research goals, with professional companion screening and detection services available upon request.
Application FieldsBinding Specificity Evaluation: Assessing the specific binding profiles of glycan-interacting proteins and targeted antibodies (such as broadly neutralizing HIV-1 or antiviral SARS-CoV-2 antibodies). Pathogen & Interactome Research: Investigating complex structural interactions between defined N-sugar chains and diverse biological targets, including viruses, bacteria, whole cells, cell lysates, serum, vesicles, or isolated proteins. Pathological Biomarker Discovery: Exploring abnormal N-glycosylation mechanisms linked to cancers, specific autoimmune diseases, and congenital disorders of glycosylation (CDG).
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