ImmunoArrayᵀᴹ O-Glycan Microarray (CAT#: NA-0726-FY35)

The O-Glycan Microarray is a high-sensitivity carbohydrate-binding matrix engineered to systematically map interactions with oxygen-linked oligosaccharides. Displaying 94 structurally distinct O-glycan variants-including advanced chemoenzymatic O-mannosyl and O-GalNAc lines-immobilized across an 8- or 16-subarray configuration, this high-throughput tool resolves target binding specificities from minimal sample volumes. Extensively cited in high-impact glycobiology literature for its synthesis accuracy and functional depth, this platform enables researchers to decode how dense mucin-type sugar structures modulate host tissue scaffolding, immune checkpoint tolerance in tumors, and neurodegenerative disease progressions.

Specifications
SizeMulti-array slide format featuring 8 or 16 identical sub-arrays per chip, enabling parallel multi-sample profiling. It accommodates a total of 94 distinct O-glycan structural variations plus controls.
Throughput LevelHigh-throughput (enables the parallel analysis of 8 to 16 samples on a single chip, delivering rapid and reliable ligand-binding results).
Arraying TechnologyMultiplex glycan microarray technology where 94 specific O-glycan structural variations are orderly printed onto the sub-arrays of a solid slide surface; molecular binding interactions (such as the AIA lectin binding model resolved via biotin-streptavidin-Cy3 chemistry) are captured and measured using a microarray slide scanner at a 532 nm wavelength.
Quality ControlIntegrated positive controls are embedded within each sub-array layout to demonstrate expected target-ligand binding signals, verifying correct grid alignment and overall assay validity.
Features94 Well-Defined Structural Targets: Features a diverse panel of 94 distinct O-glycan architectures, including O-mannosyl and O-GalNAc modular layouts. High Sensitivity & Specificity: Specially optimized to identify subtle variations in terminal sugars, core extensions, and threonine/serine linkage environments. Flexible 8 or 16 Sub-Array Format: Designed with 16 or 8 identical testing zones per slide to facilitate streamlined multi-variable comparative screening. Ultra-low Sample Volume: Employs a simplified, highly efficient micro-assay format requiring only minimal biological sample sizes. Customization & Service Support: Fully customizable to meet individual research goals, with professional companion assay screening and detection services available upon request.
Application FieldsBinding Specificity Evaluation: Assessing the precise carbohydrate-binding preferences of O-glycan-interacting host proteins (such as AIA lectins) and target antibodies. Pathogen Host-Entry Research: Investigating complex structural interactions between defined O-linked sugar chains and viruses or bacteria that target mucosal coatings during invasion. Onco-Immunology & Neuroinflammation Profiling: Investigating truncated or abnormal mucin O-glycans that promote tumor self-tolerance, mapping cell surface alterations in malignant tissues, and analyzing altered O-glycosylation paths of tau proteins tied to neuroinflammation and Alzheimer's disease. Interactome & Cellular Profiling: Exploring binding activities with diverse biological targets including whole cells, cell lysates, serum, and vesicles.
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For Research Use Only | Not For Clinical Use

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