ImmunoArrayᵀᴹ Systemic Autoimmune Disease-Related Autoantibody Detection Service (CAT#: NA-0726-FY27)

Developed by Creative Biolabs, the Systemic Autoimmune Disease-Related Autoantibody Detection Service leverages an advanced, high-sensitivity protein microarray platform to profile antibody signatures against 120 curated autoantigens. Available in two distinct versions, this high-throughput service immobilizes purified antigens on a 3D surface to preserve their native conformations. By extracting multiplexed profiles of IgG, IgM, or IgA from just a 5 μL biofluid sample, it provides translational medicine researchers with a powerful, highly cost-effective tool for discovering clinical biomarkers, deciphering complex systemic pathogenesis, and constructing multi-parametric diagnostic and prognostic models.

Specifications
Size16-sample format per slide; features advanced multiplexing capable of profiling>120 targets per well (encompassing the 120 specific systemic disease-related antigens and internal controls).
Throughput LevelHigh-throughput (processes 16 samples per slide simultaneously, with support for parallel operations across multiple slides).
Protein Count120 types of high-quality purified antigens.
Proteome CoverageBroad systemic panel targeting 120 literature-backed host proteins highly correlated with numerous systemic autoimmune conditions.
Arraying TechnologyHigh-sensitivity antigen microarray technology (protein microarray) where purified antigens are orderly immobilized onto a three-dimensional (3D) coated surface of microchips; uses fluorescent secondary antibodies and fluorescence scanning to resolve and quantify signal intensities.
Quality ControlEach individual array integrates internal Ig and anti-Ig control pairs to ensure reliable data normalization and precise quantitative comparison.
FeaturesHigh Multiplexing: Screens>120 autoantibodies concurrently in a single well, far outperforming traditional single-target ELISA methods. Version Flexibility (V2 vs. V3): Features two specialized versions with a 19-antigen variance to allow specific tracking of inflammatory myositis. Dual-Isotype Detection: Simultaneously detects two antibody types (any combination of IgG, IgM, or IgA) on a single array to maximize data output while minimizing required sample. Ultra-low Sample Volume: Requires only 5 μL of serum or other body fluids, heavily conserving clinical specimens. High Sensitivity & Wide Dynamic Range: Operates within a broad signal dynamic range from 1 to 65000. Cost-Effective: Delivers robust, multi-parametric profiles at less than 1/10 of the cost of traditional ELISA kits. Semi-Quantitative: Supports relative quantification derived from established standard curves.
Application FieldsSystemic Autoimmune Disorders: Comprehensive mapping, early warning, and biomarker profiling for conditions like Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE), Type I Diabetes, muscular dystrophy, inflammatory myositis, Mixed Connective Tissue Disease (MCTD), Sjögren's syndrome, scleroderma, polymyositis, dermatomyositis, etc. Translational & Clinical Research: Large-scale immune monitoring across allergic diseases, infectious diseases, brain nerve disorders/neurological impairments, oncology (cancer biomarkers/immunotherapy toxicity monitoring), vaccine R&D/post-vaccination monitoring (e.g., SARS-CoV-2, RSV, influenza), organ transplantation evaluation, drug screening, and clinical trials.
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