NAA and Sjogren's Syndrome
Autoantibodies are a major component of Sjogren's Syndrome (SS), and the prevalence of anti-nuclear antibodies (ANA) in SS is ~80%. An extensive array of platforms is currently available to evaluate the ANA family of autoantibodies. Creative Biolabs is a leading provider of NAA testing and analysis services. We have a team of experienced professionals and an advanced technology platform to provide a full range of NAA services for SS research.
Description of SS
SS is one of the most common autoimmune diseases. It may exist as either a primary syndrome or as a secondary syndrome when associated with other autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, and primary biliary cirrhosis. The dominant picture is epithelitis caused by lymphocyte infiltration of exocrine glands, however, extra-glandular manifestations may affect above 50% of patients. Although the pathogenesis of SS is unknown, it is hypothesized that genetic predisposition with epigenetic modification underlies the disease and is further triggered by environmental factors. This is called a "mosaic of autoimmunity". At present, there is no common evidence-based intervention treatment, mainly symptomatic treatment. Therefore, further understanding of the pathophysiology of primary SS is crucial for finding new biomarkers and identifying new therapeutic targets.
SS Develop Pathway
The pathogenesis of primary SS may be a continuous, multi-step process leading to selective injury of the exocrine glands and to target organ dysfunction. Primary SS is the result of a complex interaction of multiple factors, including genetic and epigenetic control of immune homeostasis and gene expression, age and gender, and environmental damage. Newly discovered genetic associations in primary SS implicate disturbances in both the adaptive and the innate immune pathways.
Fig.1 Multifactorial pathogenesis of primary SS: interferons as culprits in the self-amplifying pathogenic loop. (Maria, 2015)
NAA Services for SS at Creative Biolabs
- NAA Services for Anti-Ro Autoantibodies
- NAA Services for Anti-La Autoantibodies
- NAA Services for Rheumatoid Factor (RF)
- NAA Services for Anti-mitochondrial Antibody (AMA)
- NAA Services for Anti-centromere Antibody (ACA)
- NAA Services for Anti-muscarinic 3 Receptor (M3R) Antibody
SS Related Products at Creative Biolabs
The hyperactivity of B cells and the long-term survival of plasma cells give rise to widespread autoantibodies. Autoantibodies are a key serological feature of primary SS. The main autoantibodies found are antinuclear antibody (ANA), RF, anti-Ro/SSA, and anti-La/SSB. Early detection of these antibodies may be important, especially anti-Ro/SSA antibodies in asymptomatic pregnant women.
| Target | Product Name | Cat. No. |
|---|---|---|
| SSB autoantibody | Human SSB Autoantibody (IgG) ELISA kit | NAK-007 |
| Extractable nuclear antigens (ENA) autoantibody | Human Extractable nuclear antigens (ENA) Autoantibody (IgG) ELISA kit | NAK-038 |
| AMA-M2 autoantibody | Human AMA-M2 Autoantibody (IgG) ELISA kit | NAK-013 |
As one of the largest NAA services and products suppliers, Creative Biolabs has expertise and capabilities in providing high-quality NAA solutions. At Creative Biolabs, you can count on our skilled and passionate workforce to find the most suitable NAA path. If you are interested in our NAA services and products, please contact us for more information.
Reference:
- Maria, N.I.; et al. The clinical relevance of animal models in Sjögren’s syndrome: the interferon signature from mouse to man. Arthritis research & therapy. 2015, 17(1): 1-12.
Related Services:
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- NAA Associated Rheumatic Diseases
- NAA Associated Celiac Disease
- NAA Associated Sjögren's Syndrome (SS)
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