NAA Services for Anti-Adrenal Autoantibodies
Creative Biolabs has successfully constructed a series of improved and innovative NAA platforms to provide fast and high-quality services for our worldwide customers. With over a decade of experience and the state-of-the-art technical platforms, we can totally meet your project requirements and budgets in the anti-adrenal autoantibodies marker services for diseases diagnosis and related researches. Our professional team has been optimized to help you succeed in your NAA program.
Background of Anti-Adrenal Autoantibodies
Anti-adrenal autoantibodies, also named as adrenal cortex antibodies, are a group of autoantibodies that specifically target autoantigens on the adrenal cortex. They can lead to several renal disorders or autoimmune diseases, such as autoimmune adrenalitis, autoimmune polyglandular syndromes, and other related diseases. Antibodies against steroid 21-hydroxylases, steroid 17 alpha-hydroxylase (P450c17, 17 alpha-OH) and cytochrome P450 side-chain cleavage enzyme (P450scc) are all anti- adrenal autoantibodies that react with primate adrenal cortex and cause dysfunctions of adrenal biosynthesis.
The Role of Anti-Adrenal Autoantibodies in Adrenalitis
Adrenalitis, also known as adrenitis, is a type of adrenal glands inflammation with insufficiency of adrenaline or noradrenaline. Autoimmune adrenalitis is the most common of adrenalitis that often accompanied by other autoimmune diseases and the most frequent cause of Addison's disease. Autoimmune destruction, impaired steroidogenesis or adrenal destruction can result in adrenal insufficiency of autoimmune adrenalitis. Patients with early stages or focal adrenalitis are usually asymptomatic, but more than 90 % of the adrenal cortex is destroyed when clinical manifestations appear. Therefore, early biomarker researches are necessary to improve the diagnosis of adrenalitis.
Autoimmune adrenalitis is a kind of adrenalitis characterized by the presence of several anti-adrenal autoantibodies including anti-21-hydroxylases, anti-17 alpha-OH, and anti-P450scc, which were first identified in the serum of patients with Addison's disease in 1957. These anti-adrenal autoantibodies mainly are IgG1, IgG2, and IgG4 subclasses. The detection of high levels of adrenal cortex antibodies on cytostatic sections of adrenal glands by immunofluorescence has been the markers for autoimmune adrenalitis diagnosis for many years.
Fig.1 Immunopathogenesis of autoimmune Addison’s disease. (Bratland, 2011)
Features of our Services
- Powerful antibody research technology
- One-stop NAA services (related diseases, products, custom services, and applications)
- Best after-sale service
- Cost-effective and time-saving
What We Can Do about NAA?
Aided by our well-established platforms and experienced scientists, we can provide comprehensive NAA services, from NAA detection, NAA profiling, to NAA epitope mapping. A wide spectrum of NAA products is available for your choice.
In addition to anti-adrenal autoantibodies, Creative Biolabs is capable to provide the largest and diversiform portfolio of NAA products and services. Our proven and optimized platforms can help you quickly get satisfactory results without repeated trials. We also provide custom services based on the requirements of the clients to meet the specific demand. Please contact us for more information.
Reference:
- Bratland, E.; Husebye, E.S. Cellular immunity and immunopathology in autoimmune Addison's disease. Molecular and Cellular Endocrinology. 2011, 336(1-2): 180-190.