NAA Services for Anti-Neutrophil Cytoplasmic Antibodies (ANCA)
Creative Biolabs has advanced platforms and extensive experience in NAA (natural autoantibodies) detection and analysis services. Here we can provide high-quality services for our customers all over the world. Currently, we offer a full range of anti-neutrophil cytoplasmic antibodies (ANCA) marker services for diseases diagnosis and therapeutic monitoring. Our state-of-art technical platform and valuable suggestions for NAA will be helpful for your projects.
Background of Anti-Neutrophil Cytoplasmic Autoantibodies
Anti-neutrophil cytoplasmic antibodies are a group of sensitive and specific autoantibodies. IgG is the main type against these antigens in the cytoplasm of neutrophil granulocytes (the most common type of white blood cell) and monocytes. They were first described by Davies in 1982 in a few patients with necrotizing glomerulonephritis and symptoms of systemic vasculitis. They are found as a blood test marker for a variety of autoimmune disorders, particularly related to systemic vasculitis, so also called ANCA-associated vasculitides. Myeloperoxidase (MPO) and proteinase 3 (PR3) were identified as the main target antigens of P-ANCA and C-ANCA, amongst, P-ANCA was also found in patients with a wide range of non-vasculitic disorders such as inflammatory bowel diseases (IBD), primary sclerosing cholangitis, autoimmune liver diseases, rheumatoid arthritis (RA), malignancies and infections.
Fig.1 The inflammation cascade of ANCA-associated vasculitis.1
The Role of ANCA in Rheumatic Diseases
RA is a systemic inflammatory autoimmune disease characterized by chronic polyarthritis, eventually leading to joint erosion, and along with various autoantibodies. The autoantibodies recognized autoantigens include cartilage components, chaperones, nuclear proteins, citrullinated proteins, and enzymes. ANCA exists in a number of chronic inflammatory non-vasculitic conditions including RA. Previous research suggested that anti-neutrophil cytoplasmic antibodies detected by indirect immunofluorescence appear to have a low diagnostic value for granulomatosis with polyangiitis. However, they may have prognostic value for evaluating the course of RA.
The Role of ANCA in AIDS
Human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) is an immune disease caused by infection with HIV. HIV infection is related to an increased incidence of autoantibodies. The presence of autoantibodies (such as anti-neutrophil cytoplasmic antibodies) is significantly associated with lower CD4+ lymphocyte counts and increased mortality, which indicates a prognostic significance to detect autoantibodies in the context of HIV infection. Some cytokines are involved in the pathogenesis of AIDS, for instance, tumor necrosis factor alfa (TNF alpha) is the main one produced by the monocyte-macrophage. Then, the cytokines induce the activation of antigens such as proteinase 3 (Pr3) or myeloperoxidase (MPO) which are the targets of ANCA. It has been reported that ANCA in HIV infected patients is responsible for autoimmune phenomena in relation to opportunistic infections.
What We Can Do about NAA?
We can provide comprehensive NAA services with our well-established platforms and experienced scientists, include NAA detection, NAA profiling, NAA Affinity Measurement, NAA epitope mapping, and Paratope Mapping. A wide spectrum of NAA products is available for your choice.
Features of Our Services
- Advanced platform
- Professional scientists
- High efficiency and timely
- Cost-effective service
As one of the most professional service providers in NAA products and services, Creative Biolabs offers optimized services to help you detect ANCA using the most comprehensive approaches in a timely and cost-effective manner. We also provide custom services based on the requirements of the clients to meet specific demands. Please contact us for more information.
Reference:
- Almeida, Sofia, Pedro Maia Neves, and Vital Da Silva Domingues. "Pathogenesis and biomarkers in ANCA-associated vasculitis." Vessel Plus 5 (2021): 44.