Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsNeurexins (NRXNs) are a class of presynaptic cell adhesion proteins responsible for the connection of neurons at the synapse. They are widely expressed in all brain regions as well as neuron types. NRXNs contain a single transmembrane domain. The intracellular cytoplasmic region interacts with proteins associated with exocytosis, and the extracellular domain binds to the postsynaptic neuroligins (NLGNs) in a Ca2+-dependent manner. The NRXNs-NLGNs binding plays an essential role in the formation of excitatory or inhibitory synapses and mediation of the neuronal network. NRXNs can promote neuroligins accumulation in postsynaptic cells to a dendritic surface, leading to postsynaptic responses, such as clustered neurotransmitter receptors and other postsynaptic proteins. And the NLGNs can also block presynaptic signals by recruiting neurexins. Mutations in NRXNs and NLGNs are involved in nervous disorders, such as autism, cognitive diseases.
Here shows part of NRXNs in humans including NRXN1 and NRXN2, encoded by NRXN1 and NRXN2 genes, respectively. In mammals, NRXNs are encoded by three different genes (NRXN1-3). Among those, NRXN1 and NRXN3 genes are the largest of mammalian genes, with sizes of about 1.1 and 1.6 Mb, respectively. While NRXN2 is relatively smaller, with a length of 110 kb.
Aided by cutting-edge MemDX™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Meanwhile, our MemDX™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
