Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsNeuromedin receptor family (NMRs) belongs to GPCRs superfamily, whose endogenous ligand is neuromedin, one type of neuropeptides and can be used by neurons in signal communications. Different neuromedins are discovered and entitled based on their distribution and physiological roles. Corresponding with the ligands, neuromedin U receptor (NMUR) and neuromedin B receptor (NMBR) are conducted in-depth study. NMUR can bind neuromedin U, the first neuropeptide isolated from the porcine spinal and widely expressed in the gastrointestinal, genitourinary and CNS. NMURs are currently divided into two subtypes: NMUR1 and NMUR2, and both of them can mediate diverse biological effects including contraction of the uterus, peripheral vasoconstriction causing hypertension and activation of the HPA axis resulting in decreased food intake via the CRH system. NMBR is the receptor of neuromedin B, which is a bombesin-related peptide and originally purified from pig spinal cord, and later shown to be present in human CNS and gastrointestinal tract. NMBR plays important roles in the regulation of endocrine and exocrine secretion, smooth muscle contraction, body temperature, blood pressure, feeding, and cell growth.
Here show partial members of NMRs, including NMUR1, NMUR2, and NMBR. NMUR1 is expressed in the periphery system (especially in the gastrointestinal tract), while NMUR2 is expressed in the CNS (especially in the substantia nigra, medulla oblongata and pontine reticular formation). NMBR is widespread in the CNS, olfactory nucleus and thalamic regions with high levels, and in lower levels in the frontal cortex, dendate gyrus, amygdala, and dorsal raphe.
Aided by cutting-edge MemDX™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Meanwhile, our MemDX™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
