Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsNicotinic acetylcholine receptors (nAChRs) are a member of the “Cys-loop” receptor superfamily of ligand-gated ion channels including GABAA, glycine, as well as serotonin (5-HT3) receptors. These subunits combine to constitute various nAChR subtypes with diverse expression patterns, functional properties, and pharmacological characteristics. Since cholinergic innervation is pervasive and the nAChR expression is extremely wide, virtually all brain area is influenced by nicotinic mechanisms. nAChRs can be classified into neuronal and non-neuronal subtypes. The neuronal subtypes of these receptors, such as, the α7 and α4β2 isoforms, are involved in neurobehavioral processes that involve anxiety, nicotine-seeking behavior, the central processing of pain, food intake, and several cognitive functions like learning and memory. Neuronal nAChR dysfunction is implicated in the pathophysiology of lots of neurological disorders, and animal behavioral studies are helpful models to assess the effects of compounds that react on these receptors.
There are sixteen homologous nAChR subunits in mammalian encoded by a multigene family. Here shows the part of neuronal nAChRs in humans. nAChRs consist of five subunits arranged around a water-filled pore. Based on the adjacent cysteine (Cys) groups in the extracellular domain of only α subunits, neuronal subtypes are divided into the alpha (α2-α7, α9, and α10) and beta (β2-β4) classifications. Much of the structural and functional diversity of neuronal nAChRs derives from kinds of possible subunit combinations.
| Human Neuronal nAChR Family Members | ||||
| CHRNA10 | CHRNA2 | CHRNA3 | CHRNA4 | CHRNA5 |
| CHRNA6 | CHRNA7 | CHRNA9 | CHRNB2 | CHRNB3 |
| CHRNB4 | ||||
Assisted with powerful Magic™ membrane protein production platform, Creative Biolabs is a pleasure to offer the preparation of these membrane proteins in requirements through varieties of strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Moreover, our Magic™ membrane protein antibody discovery platform can help to screen antibodies against these protein targets, even fully humanized antibodies, by different approaches including phage display technology, hybridoma technology, etc. Besides, we also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
