Neuronal membrane glycoprotein M6 family consists of two membrane glycoproteins, GPM6A and GPM6B, which are highly expressed on central neurons and certainly polarized epithelia from the early developmental stage. Neuronal membrane glycoprotein GPM6A expression is limited to neurons, while GPM6B is expressed in both neurons and glia. Neuronal membrane glycoprotein GPM6A and GPM6B were proven to be highly homologous to the myelin proteolipid protein (PLP). Proteolipid proteins are expressed in most brain regions and are suggested to play a role in cellular housekeeping functions, such as membrane trafficking and cell-to-cell communication. And the homology with PLP indicated that the two membrane proteins in this family arose from a primitive gene that encoded a membrane pore-forming protein.
Neuronal membrane glycoprotein M6 has been suggested to play a critical role in neural development, which affects neurite outgrowth of cultured cerebellar neurons, as well as their survival. Accordingly, the M6 family has been considered to be an attractive candidate target to test in Rett syndrome, Aicardi syndrome, etc. Here, we make the detailed introduction of GPM6A and GPM6B for your review.
By utilizing our Magic™ membrane protein production platform, scientists in Creative Biolabs are well-experienced in providing the preparation services of these membrane proteins given above in required formats through different strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, with stable cell line.
Moreover, Magic™ membrane protein antibody discovery platform in Creative Biolabs can be applied in developing antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more details.