Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsNeuropeptide receptors represent a large subfamily of GPCRs with 7 transmembrane domains, which can bind various neuropeptides. As neuronal signaling molecules, neuropeptides are used by neurons to communicate with each other to regulate the physiological reactions in specific ways, including metabolism, reproduction, social behaviors, learning, and memory. Neuropeptides receptor family comprises a large number of subtypes, mainly include neuropeptide Y receptors (NPYRs), neuropeptide B/W receptors (NPBWRs), neuropeptide S receptors (NPSRs), and neuropeptide FF receptors (NPFFRs). In human, there have been identified four neuropeptide Y receptors (NPY1R, NPY2R, NPY4R, NPY5R) and everyone can couple to pertussis toxin-sensitive Gi proteins via the inhibition of adenylate cyclase. Activated NPYRs release the Gi subunit which inhibits the production of the second messenger cAMP from ATP. NPBWRs are predominantly expressed in the CNS (substantia nigra and hypothalamus) and in the periphery (reproductive and immune tissues, liver, stomach, and trachea), suggesting a possible role in locomotor control, the release of pituitary hormones, immune reaction and propagation. NPSR is widely distributed in the brain areas (cortex, hypothalamus, amygdala and multiple midline thalamic nuclei), which are functionally associated with emotional behavior, promoting arousal and anxiolytic-like effects. Containing an RF-amide motif which has a high affinity for the pain modulatory peptide neuropeptide NPFF, NPFFRs are believed to be involved in pain modulation, opioid tolerance, cardiovascular regulation, memory and neuroendocrine regulation.
Here show several members of neuropeptide receptors, including NPBWR1, NPBWR2, NPY1R, NPY2R, NPY4R, NPY5R, NPFFR1, NPFFR2, and NPSR1. Different neuropeptide receptor subtypes can have distinct physiological properties and a majority of them are important drug targets for therapies.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
