Africa green monkey is a genus of medium-sized primates from the family of Old World monkeys. Due to their strong similarities to humans across physiologic, developmental, behavioral, immunologic, and genetic levels, Africa green monkeys are essential models for a wide spectrum of biomedical research.
Background of Africa Green Monkey
African green monkey (Chlorocebus sabaeus) is an Old World monkey which is almost found only in West Africa. This species is also widely known as sabaeus or callithrix monkey, and the typical body characteristics including golden green fur and pale hands and feet. Like other monkeys, they have slender, half-curled tails. The tips of their tails are golden yellow as are the backs of the thighs and cheek whiskers. The green monkey is a heteromorphic species with males larger than females. Males weigh up to 4 to 8 kg, with an average length of 500 mm, while females weigh between 3.5 and 5 kg, with a length of about 450 mm. In Africa, green monkeys live in sub-Saharan forests, bordering forest grasslands. Like other members of the genus Cynomolgus, the green monkeys are highly social and usually appear in groups. Among these groups, there is a distinct social hierarchy, which is proved by combing behavior and gender relations.
Africa Green Monkey in Biomedical Research
The most prominent uses of African green monkeys include: as a substitute for rhesus monkeys, as a tool for using in the study of neurobehavioral phenotypes, neurodegeneration, neuroanatomical variation, immune system, infectious diseases, and metabolic phenotypes. They are an ideal gene discovery system and are likely to increase their use dramatically in the next few years. Moreover, African green monkeys are important model organisms for the study of AIDS. Unlike most other non-human primates, they naturally produce hypertension and simian immunodeficiency virus (SIV) which is the ancestors of human immunodeficiency virus (HIV). Thus, valuable advances in HIV/AIDS can be directly linked to experiments in these monkeys.
Since the 1950s, African green monkeys and derived products have been the focus of many scientific studies. Cell lines extracted from their tissues are still used to produce polio and smallpox vaccines. Vero cells, from kidney tissue, are a continuous cell line of African green monkeys, which are widely used in immunology and infectious diseases. Widespread cytopathic effects and plaque formation in Vero cell culture have made it possible to develop an efficient and repeatable direct technique to demonstrate multiple viruses and specific neutralizing antibodies. Therefore, Vero cell lines provide virologists with another tool for diagnosis and research and may provide an advantage for mass production of vaccine viral preparations.
Creative Biolabs provides high-quality African green monkey-derived products including whole blood, serum, plasma, primary cells, tissue samples and body fluid for a variety of in vitro testing applications. Moreover, we provide standard formats as well as customized tissue preparations to meet your research needs. Please contact us for more information.