What anticoagulants are used in the plasma collection?

We use EDTA or heparin, depending on the requirements of the research.

Can the plasma be used in coagulation studies?

Yes, our baboon plasma is suitable for various coagulation assays.

Non-Human Primate (NHP) Plasma Products, Baboon, Plasma

Category: Non-Human Primate (NHP) Plasma Products
Tag: Baboon,Plasma

Baboon Plasma (NHP-BP013)

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Product Overview Detailed Product Description Technical Specifications Downloadable Resources Published Data FAQs Customer Reviews

Baboons are a kind of large and robust monkeys with orthographic processing abilities. This monkey-derived product is collected from Baboon's veins or arteries tissue. The sample is high-quality and has been confirmed as negative for Herpes B Virus, retroviruses, SIV, SRV, & STLV. It can be applied in a life science laboratory to conduct a number of biochemical experiments including PCR, WB, immunoprecipitation, immunofluorescent flow cytometry, and so forth.

Source: Healthy baboon

Purity: No hemolysis or clotting.

Applications: Suitable for various research fields including biomarker research, pharmacology, and toxicology.

Storage Conditions: Store at -20 °C or -80 °C. Avoid freeze-thaw cycle.

Collection Method: Plasma is collected from rigorously screened healthy donors, and the collection process strictly adheres to animal welfare requirements. Obtained through centrifugation processing of anticoagulated whole blood, plasma does not contain blood cells or platelets and serves as a primary source for biomarkers.

Quality Control: Strict accordance with biomedical standards.

Available Formats: Frozen

Baboon Plasma (NHP-BP013) Data Sheet: Detailed information. datasheet

The article explores the thrombin generation profile in Chacma baboons (Papio ursinus), commonly used in preclinical models for hemostatic diseases like acquired thrombotic thrombocytopenic purpura and bacterial sepsis-induced disseminated intravascular coagulation.

This study assesses thrombin generation parameters such as lag times, peak heights, times-to-peak, velocity indexes, and Endogenous Thrombin Potentials (ETPs) in 40 adult Chacma baboons, comparing them with normal human plasma.

The study found that while lag times of all baboons fell within the human reference interval, most had times-to-peak and velocity indexes significantly different from humans. Notably, 97.5% of the baboons had an ETP above the human reference interval, indicating greater overall thrombin generation. The study also observed sex-related differences; male baboons had less potent thrombin generation than females, with longer lag times and lower peak thrombin concentrations and ETPs.

This significant finding implies that Chacma baboons, particularly females, have greater overall endogenous thrombin generation potential than humans. This difference is crucial for designing future baboon model experiments and evaluating novel therapies involving the hemostatic system.

Fig. 1 Baboon thrombin generation curve ranges, compared with a selection of normal human plasmas, ran for 90 min.¹ The graph depicts the mean thrombin concentrations of all 40 baboons and 13 normal human plasmas, ± 1SD at the various indicated timepoints. The lower line represents the mean—1SD, and the upper line represents the mean + 1SD. nM nanomolar.

Fig. 2 Comparison of Papio ursinus thrombin generation parameters of all baboons (n = 40), and all subgroups, with corresponding human data (n = 44).¹

Reference

J. Joubert .,et al. "The thrombin generation capability of the Chacma baboon (Papio ursinus): implications for haemostatic disease models" Nature. Scientific Reports.(2023) 13:22968. Distributed under Open Access license CC BY 4.0, without modification.

Q 1: What anticoagulants are used in the plasma collection?
A: We use EDTA or heparin, depending on the requirements of the research.
Q 2: Can the plasma be used in coagulation studies?
A: Yes, our baboon plasma is suitable for various coagulation assays.

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Your research is unique, and we understand that standard products may not always fit. Our team of experts specializes in custom NHP sample collections. We can design a tailored protocol to meet your specific research requirements, including samples with unique anticoagulant types, customized volumes, or from specific disease models.