Category:
Non-Human Primate (NHP) related Antibody Products
Bax Monoclonal Antibody (I79RO) (NHP-AB173)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
Customer Reviews
This product is an antibody that was generated by immunizing mouse against amino acids 3-16 (GSGEQPRGGGPTSS) from the human protein. It is used only in in vitro assays.
Introduction:
BAX is a members of the Bcl-2 Family and plays an important role in regulation of apoptosis. Whereas Bcl-2 is commonly regarded as an anti-apoptotic protein, BAX is considered to have a pro-apoptotic function. Regulation of apoptosis is supposed to involve both homo- and heterodimerization of different isoforms of BAX and Bcl-2. The Bax gene encodes different isoforms including Bax alpha (21 kDa) and Bax beta (24 kDa), whereas both isoforms contain the BH1, BH2 and BH3 domains, Bax beta has a unique carboxyl terminus and does not contain a hydrophobic transmembrane domain. Bcl-2 is also expressed in different Isoforms. Bcl-2 beta differs in the 3' UTR and coding region compared to variant alpha. Bcl-2 beta is shorter (22 kDa) and has a distinct C-terminus compared to Bcl-2 alpha (26 kDa). BAX is a member of the BCL-2 family of proteins, which function as regulators of apoptosis. Overexpression of BAX functions to promote cell death. BAX can form homodimers and is also able to heterodimerize with other BCL-2 related proteins.
Conjugate:
None
Antibody Isotype:
IgG1
Applications:
Flow Cytometry; IF; IHC; WB
Host Species:
Mouse
Species Reactivity:
Human; Monkey
Immunogen:
Amino acids 3-16 (GSGEQPRGGGPTSS) from the human protein
Purification:
Protein G affinity chromatography
Format:
Liquid
Concentration:
0.2 mg/mL
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Storage:
Store at 4⁰C.
Target:
Bax
Clone:
I79RO
Clonality:
Monoclonal
Alternative Names:
Apoptosis regulator BAX; Bax zeta; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; Bcl-2-like protein 4; BCL2 associated X protein; BCL2-associated X protein omega; Bcl2-L-4
Entrez Gene ID:
581
- Bax Monoclonal Antibody (I79RO) (NHP-AB173) Data Sheet: Detailed information. datasheet
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For research use only. Not intended for any clinical use.
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