CD107a Monoclonal Antibody (B4A3), FITC (NHP-AB091)

• This product is an antibody conjugated with FITC that was generated by immunizing mice against a human adherent peripheral blood cells. It is used only in in vitro assays.

Detailed Product Description

• Introduction: CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily
  glycosylated type I transmembrane protein that constitutes the major sialoglycoproteins
  on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in
  extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains,
  and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed by activated T
  cells, macrophages, dendritic cells, activated platelets, tonsillar epithelium, and some
  tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular
  antigen. LAMP-1 may function in protecting the inner surface of the lysosomal membrane
  by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and
  CD107b on the surface of tumor cell lines has been associated with their enhanced
  metastatic potential where they may increase adhesion to extracellular matrix and
  endothelium.
• Conjugate: FITC
• Antibody Isotype: IgG1
• Applications: Flow Cytometry; IHC-Fr; WB; IP

Technical Specifications

• Host Species: Mouse
• Species Reactivity: African green Monkey; Human
• Immunogen: Human adherent peripheral blood cells

Product Property

• Format: Liquid
• Buffer: Supplied in PBS/NaN3
• Storage: Store at 4⁰C.

Target Information

• Target: CD107a
• Clone: B4C3
• Clonality: Monoclonal
• Alternative Names: CD107 antigen-like family member A; CD107a; LAMP-1; lysosomal-associated membrane protein 1; Lysosome-associated membrane glycoprotein 1; lysosome-associated membrane protein 1
• Entrez Gene ID: 3916