Accelerate Drug Development with Human-Relevant Insights!

Are you struggling with translational gaps in preclinical models, unpredictable immune responses to biologics, or limited efficacy in complex disease studies? Our Chimpanzee delivers unmatched translational accuracy through 96.4% genetic alignment with humans and evolutionarily conserved immune pathways, enabling robust prediction of drug safety, efficacy, and immunogenicity. Leverage our ethically sourced models, and comprehensive biological repositories to de-risk your R&D pipeline.

Distributed under CC BY 4.0, from Wiki, without modification.

Key Advantages

Chimpanzees share 96.4% genomic homology with humans, the highest among non-human primates (NHPs), making them indispensable for studies requiring human-like physiology:

• Neurological Complexity: Advanced cognitive abilities and neuroanatomical parallels support Alzheimer's, Parkinson's, and neuropsychiatric disorder modeling.
• Immunological Precision: Their immune system mirrors humans in T-cell receptor diversity, cytokine signaling, and antibody maturation, critical for evaluating biologics and vaccines.
• Metabolic Relevance: Hepatic enzyme profiles align closely with humans, ensuring accurate pharmacokinetic (PK) and toxicology data.

Applications in Drug Discovery & Development

Deploy chimpanzees across the drug development continuum to achieve regulatory-ready, human-predictive outcomes:

1. Toxicology & Safety Pharmacology: Perform investigations utilizing human-like profiles of drug metabolism and organ toxicity.

2. PK/PD & Dose Optimization: Simulate absorption, distribution, and elimination with over 90% correlation to human studies, minimizing Phase I failure rates.

3. Complex Disease Models: Reproduce neurodegenerative conditions, autoimmune diseases like rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and infectious diseases such as HIV and hepatitis, employing clinically relevant endpoints.

4. Biologics & Advanced Therapies: Evaluate monoclonal antibodies, CAR-T cells, and gene therapies for immunogenicity, target interaction, and biodistribution.

5. Vaccine Efficacy Validation: Analyze both humoral and cellular immune responses to vaccines targeting pathogens, including HIV, HCV, and newly emerging viruses.

Available Biological Samples

Access rigorously validated samples for exploratory and regulatory studies:

Chimpanzee In Vivo Research Services

• Toxicology Studies: Execute repeat-dose with histopathology and biomarker analysis.
• Immunogenicity Risk Assessment: Quantify ADA/NAb responses to biologics and gene therapies using ELISA, MSD, and cell-based assays.
• Neurological Disease Modeling: Induce and monitor Alzheimer's (Aβ/tau), Parkinson's (α-synuclein), and ALS phenotypes with behavioral and imaging endpoints.
• Infectious Disease Challenges: Test antiviral compounds and vaccines for HIV, HCV, and zoonotic pathogens in controlled biocontainment.

Rigorous Quality & Animal Care

We ensure data integrity and uphold ethical standards:

• SPF Health Surveillance: Quarterly PCR testing for Herpes B, SRV, SIV, and TB is conducted.
• Veterinary Proficiency: Round-the-clock care is provided by qualified veterinarians.
• Comprehensive Animal Welfare: Adhering to international animal welfare guidelines, we implement extensive enrichment programs to maintain animal well-being.

Contact Us

With extensive expertise in preclinical drug discovery and development utilizing NHPs, our platform serves as your all-inclusive partner, offering a broad array of products and specialized services that deliver high-quality, predictive insights throughout your research and development process. Discover our Chimpanzee-derived biologics and disease model licenses to advance your preclinical program. For more information on how our expertise can benefit your project, please contact us today to design your study.