Cynomolgus macaque is a non-human primate species which is mainly distributed in the south of East Asia and Southeast Asia. It is one of the most commonly used non-human primates in biomedical research because its genome is highly homologous to human and easy to operate in experiments.
Introduction of Cynomolgus Macaque
Cynomolgus macaque (Macaca fascicularis), also known as long-tailed macaque and crab-eating macaque, is a primate species indigenous to tropical southern and Southeast Asia. Their range of activities includes virgin forests, secondary forests, mangroves and other forest areas close to water, sometimes found in rural and suburban areas. They have a wide range of food sources. In addition to crabs, fruits, leaves, small animals, and birds are the objects of their consumption. Cynomolgus macaque can obtain feeding and social behaviors through examples, indicating its behavioral homology to humans. Because it also has other characteristics in common with humans, it is widely used in biomedical research as an important animal model, such as drug evaluation. Despite their increasing importance as animal models, the cynomolgus macaque genome has not been fully characterized, hindering molecular studies of this model.
Application of Cynomolgus Macaque in Biomedical Research
Behavioral science has attracted considerable attention as a platform for studying advanced cognitive functions in humans. However, due to ethical considerations, some advanced functional and structural investigations cannot be conducted in humans. Cynomolgus macaque shares strong genetic, neuroanatomical and behavioral homology to human. Therefore, compared to non-primate behavioral models (e.g., rodents, canines), this species serves as a more suitable experimental model for neuropsychiatric research and other behavioral research. In addition, cynomolgus macaque has been recognized as a suitable model for transplantation research because of their similarity to humans in immunologic, genetic, and physiologic aspects. Moreover, they are also the preferred animal model for toxicology and efficacy studies for drug development, especially for developing vaccine candidates associated with emerging dangerous pathogens. For example, due to their high level of MHC class I allele sharing, cynomolgus macaques may serve as the best alternative of rhesus monkey for studying HIV/AIDS. And as hepatitis B virus is naturally occurring and transmissible in cynomolgus macaques, thus making cynomolgus macaques good nonhuman primate animals for researches on hepatitis B virus.
In addition to being used as an animal model, biological products from cynomolgus macaque also play a very important role in in vitro studies. Peripheral blood mononuclear cells (PBMCs) isolated from cynomolgus monkeys have been used to explore Fc-dependent function of antibodies. Cynomolgus serum is applied in various immunoassays such as ELISA, ELISPOT and western blots in initial blocking steps. Serum or plasma from these animals can also be used in studying in vitro PK profiles of novel therapeutics.
For many years, Creative Biolabs has focused on providing non-human primate products to customers around the world and accelerating their projects. We offer cynomolgus macaque-derived serum, plasma, primary cells, body fluids and tissue samples to pharmaceutical, biotechnology, diagnostics, and analytical lab industries. We also provide a variety of customized research products and related services according to your specific requirements. If you have any other questions about this, please feel free to contact us.