Why are Cynomolgus Monkey Hepatocytes considered ideal for drug metabolism and pharmacokinetic studies?

Cynomolgus Monkey Hepatocytes are highly valued in pharmacological research due to their close physiological and genetic similarities to humans. These hepatocytes offer a reliable non-human primate model for studying drug metabolism, toxicity, and pharmacokinetic profiles. Their use facilitates a more accurate prediction of human responses to pharmaceutical compounds, thereby enhancing the drug development process and ensuring safety and efficacy. The hepatocytes' compatibility with various in vitro assays for phase I and phase II metabolism studies further solidifies their importance in preclinical research.

Does cryopreservation impact the viability and functionality of Cynomolgus Monkey Hepatocytes?

Cryopreservation is a critical process that allows the long-term storage of Cynomolgus Monkey Hepatocytes without significantly affecting their viability or functionality. Advanced cryopreservation techniques ensure that these hepatocytes retain high viability, proper cell morphology, and metabolic activity upon thawing. This is essential for maintaining consistent and reliable results in drug metabolism and toxicity assays. However, the success of cryopreservation can depend on various factors, including the cryoprotectant used, freezing rates, and thawing procedures. Our scientists typically follow stringent protocols to maximize cell recovery and functional integrity post-thaw.

NHP Hepatocyte, Stellate Cell, Kupffer Cell Products, Cynomolgus Monkey, Hepatocytes

Category: NHP Hepatocyte, Stellate Cell, Kupffer Cell Products
Tag: Cynomolgus Monkey,Hepatocytes

Cynomolgus Monkey Cryoplateable Hepatocytes (NHP-PC138)

Product Overview Detailed Product Description Technical Specifications Shipping and storage Downloadable Resources FAQs Customer Reviews

Cynomolgus monkey is a commonly used primate in medical experiments, specifically those related to neuroscience and disease. Cells are in a cryopreserved state from the same day when they are separated. The product is often used in induction, toxicity, and transport research.

Source: Healthy cynomolgus monkey

Purity: ≥ 85%

Applications: Suitable for a wide range of safety assessment and functional assays.

Organ/Tissue: Liver

Cell Type: Hepatocytes

Species: Cynomolgus monkey

Cryopreservation: Cryopreserved with appropriate cryoprotectant.

Quality Control: Rigorously control cell purity and viability.

Cell Status: Cryopreserved

Shipping: Cryopreserved cells are shipped with dry ice overnight. Upon receipt, promptly transfer the frozen cells to liquid nitrogen for storage until they are ready for use. It is important to note that cells should never be stored in -20 °C or -80 °C freezer.

Storage: Liquid Nitrogen (-180 °C)

Cynomolgus Monkey Cryoplateable Hepatocytes (NHP-PC138) Data Sheet: Detailed information. datasheet

Q 1: Why are Cynomolgus Monkey Hepatocytes considered ideal for drug metabolism and pharmacokinetic studies?
A: Cynomolgus Monkey Hepatocytes are highly valued in pharmacological research due to their close physiological and genetic similarities to humans. These hepatocytes offer a reliable non-human primate model for studying drug metabolism, toxicity, and pharmacokinetic profiles. Their use facilitates a more accurate prediction of human responses to pharmaceutical compounds, thereby enhancing the drug development process and ensuring safety and efficacy. The hepatocytes' compatibility with various in vitro assays for phase I and phase II metabolism studies further solidifies their importance in preclinical research.
Q 2: Does cryopreservation impact the viability and functionality of Cynomolgus Monkey Hepatocytes?
A: Cryopreservation is a critical process that allows the long-term storage of Cynomolgus Monkey Hepatocytes without significantly affecting their viability or functionality. Advanced cryopreservation techniques ensure that these hepatocytes retain high viability, proper cell morphology, and metabolic activity upon thawing. This is essential for maintaining consistent and reliable results in drug metabolism and toxicity assays. However, the success of cryopreservation can depend on various factors, including the cryoprotectant used, freezing rates, and thawing procedures. Our scientists typically follow stringent protocols to maximize cell recovery and functional integrity post-thaw.

Pioneering Tool in Drug Development
As a researcher focused on drug metabolism and toxicity, finding reliable and physiologically relevant models is crucial. The Cynomolgus Monkey Cryoplateable Hepatocytes from Creative Biolabs have been a game-changer for our lab. Their high viability and functional integrity post-thaw have allowed us to conduct more accurate and reproducible ADME-Tox studies, bridging the gap between preclinical testing and human trials. The detailed product information and support provided have significantly enhanced our research outcomes, making these hepatocytes an indispensable tool in our drug development pipeline.
Exceptional Quality and Consistency
I've been using Cynomolgus Monkey Cryoplateable Hepatocytes from Creative Biolabs for over a year now, and I'm consistently impressed by the quality and reliability of these cells. They have proven to be an excellent model for studying drug-drug interactions and enzyme induction, which are critical aspects of pharmacokinetic research. The cryopreservation technology ensures that we have access to high-quality hepatocytes whenever we need them, without the variability often associated with fresh cells. The customer service and technical support have also been outstanding, helping us optimize our protocols for maximum efficiency.

Click the button below to contact us or submit your feedback about this product.

Fig.1 Obesity can be counteracted by gene regulation.

Your research is unique, and we understand that standard products may not always fit. Our team of experts specializes in custom NHP sample collections. We can design a tailored protocol to meet your specific research requirements, including samples with unique anticoagulant types, customized volumes, or from specific disease models.