Category:
Non-Human Primate (NHP) related Antibody Products
Estrogen Receptor beta Monoclonal Antibody (C2BR1) (NHP-AB213)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
Customer Reviews
This product is an antibody that was generated by immunizing mouse against C-terminus fragment of recombinant human Estrogen Receptor beta protein was. It is used only in in vitro assays.
Introduction:
Estrogen Receptor beta (ER beta, NR3A2) protein is approximately 55kD, though multiple isoforms ranging from 36-59kD have been described. Human ER beta was initially cloned and characterized from testis. Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Estrogen receptor beta (ER beta) binds estrogens with an affinity similar to that of estrogen receptor alpha. Some ER beta isoforms dominantly inhibit the activity of estrogen receptor alpha in reproductive tissues.
Conjugate:
None
Antibody Isotype:
IgG2a
Applications:
Flow Cytometry; IF; IHC; WB
Host Species:
Mouse
Species Reactivity:
Horse; Human; Monkey; Mouse; Pig; Rat; Sheep
Immunogen:
C-terminus fragment of recombinant human Estrogen Receptor beta protein was
Purification:
Protein G
Format:
Liquid
Concentration:
0.2 mg/mL
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Storage:
Store at 4⁰C. Avoid freeze-thaw cycles.
Target:
Estrogen Receptor beta
Clone:
C2BR1
Clonality:
Monoclonal
Related Disease:
ER beta is found widely in many tissues throughout the body and can act as a potent tumor suppressor, playing a crucial role in many cancer types such as prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain Disease and risk of cardiovascular disease.
Alternative Names:
ER beta is found widely in many tissues throughout the body and can act as a potent tumor suppressor, playing a crucial role in many cancer types such as prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain Disease and risk of cardiovascular disease.
Entrez Gene ID:
2100
- Estrogen Receptor beta Monoclonal Antibody (C2BR1) (NHP-AB213) Data Sheet: Detailed information. datasheet
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