HLA-DRB1 Monoclonal Antibody (JES15A) (NHP-AB134)

• This product is an antibody that was generated by immunizing mouse against activated human peripheral blood mononuclear cells. It is used only in in vitro assays.

Detailed Product Description

• Introduction: HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
• Conjugate: None
• Antibody Isotype: IgG2aκ
• Applications: Flow Cytometry; IF; WB

Technical Specifications

• Host Species: Mouse
• Species Reactivity: Baboon; Chimpanzee; Dog; Human; Monkey
• Immunogen: Activated human peripheral blood mononuclear cells

Product Property

• Purification: Protein G affinity chromatography
• Format: Liquid
• Concentration: 0.2 mg/mL
• Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
• Storage: Store at 4⁰C.

Target Information

• Target: HLA-DRB1
• Clone: JES15A
• Clonality: Monoclonal
• Alternative Names: Clone P2-beta-3; DR-16; DW2.2/DR2.2; HLA class II histocompatibility antigen, DR-1 beta chain; HLA class II histocompatibility antigen, DRB1-15 beta chain; HLA class II histocompatibility antigen, DRB1-16 beta chain; HLA class II histocompatibility antigen, DRB1-3 chain; human leucocyte antigen DRB1; lymphocyte antigen DRB1; MHC class II antigen; MHC class II antigen DRB1*15; MHC class II antigen DRB1*16; MHC class II antigen DRB1*3; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR-beta cell surface glycoprotein; MHC class II HLA-DRw10-beta
• Entrez Gene ID: 3123