Category:
Non-Human Primate (NHP) related Antibody Products
Integrin alpha 2 Polyclonal Antibody (NHP-AB389)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
Customer Reviews
This product is an antibody that was generated by immunizing rabbit against human leukocytes. It is used only in in vitro assays.
Introduction:
CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family. It is a glycoprotein with molecular weight of 150 kD, and it complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (integrin alpha 2 beta 1, or GPIa/IIa) complex. VLA-2 is an extracellular receptor for laminin, collagen, and fibronectin, and interaction with its ligands results in the activation of intracellular signaling pathways. It has reported roles in VEGF-induced angiogenesis in vivo, as well as adhesion and lymphocyte activation. CD49b is expressed by NK cells, NK-T cells, monocytes, platelets, and epithelial cells. It is also expressed on adaptive immune cells such as T and B cells, specifically on a subset of CD4+ T cells in the spleen, on intraepithelial and lamina propria lymphocytes in the intestine, as well as on a population of peripheral CD4+ type 1 T regulatory (Tr1) cells that co-express LAG-3.
Conjugate:
None
Applications:
IHC
Host Species:
Rabbit
Species Reactivity:
Dog; Gibbon; Gorilla; Human; Monkey; Pig
Immunogen:
A peptide located near the Extracellular domain of Integrin alpha 2 (Human)
Purification:
Immunoaffinity Chromatography
Format:
Liquid
Concentration:
0.7 mg/mL
Buffer:
PBS, 0.1% sodium azide
Storage:
Short term: 4˚C. Long term: Store at -20˚C.
Clonality:
Polyclonal
Alternative Names:
BDPLT9; CD49 antigen-like family member B; CD49b; Collagen receptor; GPIa; Integrin alpha-2; Platelet membrane glycoprotein Ia; VLA-2 receptor, alpha 2 subunit; VLA-2 subunit alpha; VLA2 receptor
Entrez Gene ID:
3673
- Integrin alpha 2 Polyclonal Antibody (NHP-AB389) Data Sheet: Detailed information. datasheet
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For research use only. Not intended for any clinical use.
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