Non-Human Primate (NHP) Advanced Imaging & Monitoring Platform

Q: How do your platforms compare to traditional in vitro or rodent models?

While in vitro and rodent models are useful, our NHP platforms offer a higher degree of clinical relevance due to the physiological and genetic similarities to humans. This reduces the risk of failure in later-stage clinical trials by providing more predictive and translatable data. We would be happy to provide case studies to demonstrate the value of our NHP platforms.

Are you currently facing long drug development cycles, difficulty in tracking biodistribution, or challenges in ensuring the translatability of preclinical data? Our Creative Biolabs NHP Advanced Imaging & Monitoring Platforms helps you accelerate drug discovery and improve clinical relevance through a suite of integrated technologies, including real-time imaging and physiological monitoring, designed specifically for non-human primate models. This platform offers the precision and predictability needed to streamline the path to clinical trials.

Advanced Imaging & Monitoring Platforms for Translational NHP Studies

Enabling biodistribution tracking and real-time monitoring in primate models.

Overview of Our Platform

What Are Our Platforms?

Creative Biolabs' NHP Advanced Imaging & Monitoring Platforms are a comprehensive suite of tools designed to provide unparalleled insights into drug pharmacokinetics and pharmacodynamics in a highly relevant model. Our platforms integrate state-of-the-art imaging modalities with real-time physiological monitoring to non-invasively track therapeutic agents and assess their effects with a level of precision that is essential for translational success.

Drug biodistribution and target engagement
Gene therapy vector delivery to specific organs
Tumor response to novel oncology therapeutics

Why Choose Our Platforms?

Choosing an advanced imaging and monitoring platform for your preclinical studies is crucial for mitigating R&D risk and accelerating your path to the clinic. The inherent physiological and genetic similarities between NHPs and humans make these models invaluable for bridging the gap between bench and bedside. However, the complexity of these models requires specialized tools and expertise to extract meaningful data.

Creative Biolabs' platforms address the pain points of fragmented data and lack of standardization. By integrating multiple modalities and adhering to rigorous quality control standards, we reduce the uncertainty often associated with traditional methods. Our platforms provide the high-quality, reproducible data needed to support Investigational New Drug (IND) submissions and enhance the predictability of clinical outcomes. By consolidating these services, we offer a streamlined process that accelerates data acquisition and project timelines, allowing your team to make informed decisions faster.

Macaque Templates and Atlases. (OA Literature) Fig.1 Templates and atlases for Macaques.¹

Key Benefits of Our Platforms

Data Highly Predictive of Human Outcomes: Utilizing NHP models for unparalleled translational potential.
Multi-Platform Integration: Combines various imaging and monitoring technologies for a holistic view.
Precision and Efficiency: Streamlined workflows for rapid and accurate project execution.
Supports IND Submission: Generates high-quality data necessary for regulatory filings.

Core Capabilities of Our Platforms

MRI / fMRI Scanners: Provides high-resolution anatomical and functional data, enabling non-invasive visualization of drug biodistribution and brain activity changes.
PET / CT / SPECT Systems: Facilitates the quantitative and longitudinal tracking of radiolabeled compounds to assess biodistribution, metabolism, and receptor occupancy.
IVIS & Optical Imaging: Enables non-invasive, real-time tracking of fluorescent or bioluminescent signals to monitor cellular and molecular processes in vivo.
Real-time Physiological Monitoring (ECG, BP, Temp): Provides continuous, high-fidelity physiological data for PK/PD correlation, ensuring patient safety and treatment efficacy.

Applications Enabled

Imaging for Gene Therapy: Non-invasively track the biodistribution and expression of gene therapy vectors in target tissues, such as the central nervous system or liver, providing critical safety and efficacy data.
Drug Delivery to the CNS: Utilize advanced techniques like Convection-Enhanced Delivery (CED) and Nose-to-Brain to bypass the blood-brain barrier and ensure uniform distribution of therapeutics for neurodegenerative diseases.
Biomarker Validation: Correlate imaging findings with physiological and molecular biomarkers to establish reliable readouts for disease progression and treatment response.

Deliverables

Processed Datasets: Includes raw imaging data and formatted physiological data files, standardized for ease of analysis.
QC Logs & Metadata: Comprehensive documentation of all data acquisition, including species, donor information, and quality assurance metrics.
Statistical Analysis Summary: Detailed reports with statistical interpretations of the data and a clear summary of key findings.
Customized Reports: Tailored study reports with figures, tables, and a discussion of results, ready for presentation or publication.

Frequently Asked Questions

Q: How does Creative Biolabs ensure the quality of the imaging data?

A: We use standardized protocols and dedicated quality assurance measures, to ensure our data is of the highest quality and is highly reproducible. We also provide raw data and detailed metadata so you can perform your own quality checks. Let's discuss our specific quality control measures and how they can benefit your study.

Q: What is the typical turnaround time for a project?

A: Our project timelines are tailored to the specific study design, but our integrated platforms and experienced team enable rapid project initiation and efficient data acquisition. This streamlined process minimizes delays, allowing you to get results when you need them. Contact our team to discuss your specific project needs and receive a detailed project timeline.

Q: Can your platforms accommodate complex, multi-modal studies?

A: Absolutely. Our strength lies in our ability to integrate multiple modalities—such as MRI with PET/CT—to provide a comprehensive view of drug behavior. We can also integrate physiological monitoring to correlate imaging results with real-time biological effects. We invite you to schedule a consultation to design a customized study for your unique research questions.

Q: How do your platforms compare to traditional in vitro or rodent models?

A: While in vitro and rodent models are useful, our NHP platforms offer a higher degree of clinical relevance due to the physiological and genetic similarities to humans. This reduces the risk of failure in later-stage clinical trials by providing more predictive and translatable data. We would be happy to provide case studies to demonstrate the value of our NHP platforms.

Q: What kind of support is available after the study is complete?

A: We provide comprehensive support, including processed datasets, detailed reports, and access to our team of scientific experts to assist with data interpretation and analysis. We also offer consulting services to help you plan your next steps and prepare for regulatory submissions.

Contact Us

Creative Biolabs' NHP Advanced Imaging & Monitoring Platforms provide the precision, efficiency, and translatability needed to accelerate your drug discovery and development process. Ready to leverage our NHP platforms for your next study? Contact Our Team for More Information and to Discuss Your Project

Reference

Messinger, Adam, et al. "A collaborative resource platform for non-human primate neuroimaging." Neuroimage 226 (2021): 117519. Distributed under Open Access license CC BY 4.0, without modification. DOI: https://doi.org/10.1016/j.neuroimage.2020.117519