Category:
Non-Human Primate (NHP) related Antibody Products
p27 Kip1 Monoclonal Antibody (ERb45) (NHP-AB235)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
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This product is an antibody that was generated by immunizing mouse against purified human GST-p27 fusion protein. It is used only in in vitro assays.
Introduction:
p27 Kip1 functions as a negative regulator of G1 mouse expression and has been proposed to function as a possible mediator of TGFb induced G1 arrest. p27 Kip1 is an important regulator of cell cycle progression, a potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. p27 Kip1 forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. p27 Kip1 acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichiometry. p27 Kip1 has a molecular weight of approximately 27kDa and the degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
Conjugate:
None
Antibody Isotype:
IgG1κ
Applications:
Flow Cytometry; IF; IHC; WB
Host Species:
Mouse
Species Reactivity:
Human; Monkey; Mouse; Rat
Immunogen:
Purified human GST-p27 fusion protein
Purification:
Protein G affinity chromatography
Format:
Liquid
Concentration:
0.2 mg/mL
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Storage:
Store at 4⁰C. Avoid freeze-thaw cycles.
Clone:
ERb45
Clonality:
Monoclonal
Alternative Names:
CDN1B; Cyclin-dependent kinase inhibitor 1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1); Cyclin-dependent kinase inhibitor p27; P27 CDKN1B; p27(KIP1); p27Kip1
Entrez Gene ID:
1027
- p27 Kip1 Monoclonal Antibody (ERb45) (NHP-AB235) Data Sheet: Detailed information. datasheet
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For research use only. Not intended for any clinical use.
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