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Rhesus Monkey Cerebrospinal Fluid (CSF) (NHP-BF007)

NHP Cerebrospinal Fluid (CSF) Products, Rhesus Monkey, Cerebrospinal Fluid (CSF)
Category:NHP Cerebrospinal Fluid (CSF) Products
Tag: Rhesus Monkey, Cerebrospinal Fluid (CSF)
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  • In biology and medicine research, the Rhesus monkey is commonly used because of its high similarity to humans. This offered product is obtained from Rhesus monkeys' brains and spinal cords. The sample is high-quality and offered in a cryopreserved or fresh state and can play an important role in lots of tests and assays including PCR, WB, immunoprecipitation, and immunofluorescent flow cytometry.

Detailed Product Description

  • Source: Healthy rhesus monkey
  • Purity: Free of foreign impurities.
  • Applications: Suitable for various research fields including biomarker research, pharmacology, and toxicology.
  • Storage Conditions: Store at -20 °C or -80 °C. Avoid freeze-thaw cycle.

Technical Specifications

  • Collection Method: Cerebrospinal fluid is collected from rigorously screened healthy donors, and the collection process strictly adheres to animal welfare requirements. Obtained through a special spinal needle, cerebrospinal fluid does not contain contamination and serves as a primary source for biomarkers.
  • Quality Control: Strict accordance with biomedical standards.
  • Available Formats: Frozen
Downloadable Resources Published Data FAQs Customer Reviews
  • Rhesus Monkey Cerebrospinal Fluid (CSF) (NHP-BF007) Data Sheet: Detailed information.

This paper focuses on the analysis of NHP (Non-Human Primate) cerebrospinal fluid (CSF) biomarkers related to neurodegenerative diseases within clinically healthy Cynomolgus and Rhesus macaque monkeys. Normative values are established within the core biomarkers: amyloid beta, tau proteins, and neurofilament light within the two species. Notably, excellent results included the differences in the concentration of biomarkers between species and sex for neurodegenerative disease modeling and research needs. It represents therefore highly valuable baseline data for future comparisons within NHP models of neurological disorders, expressing the necessity of understanding biomarker variations across different demographics of NHP species.

Species and sex comparison for cerebrospinal fluid (CSF) amyloid beta (Aβ), tau, and neurofilament light (NfL) biomarkers. CSF Aβ, tau, and NfL biomarkers measured in CSF samples obtained by a lumbar puncture (LP) in male and female cynomolgus (Cyno) (C) and rhesus macaques (R).1Fig. 1. Species and sex comparison for cerebrospinal fluid (CSF) amyloid beta (Aβ), tau, and neurofilament light (NfL) biomarkers. CSF Aβ, tau, and NfL biomarkers measured in CSF samples obtained by a lumbar puncture (LP) in male and female cynomolgus (Cyno) (C) and rhesus macaques (R).

Colony demographics and correlations of biomarkers with age.n1Fig. 2. Colony demographics and correlations of biomarkers with age.n

Reference

  1. Reference: Emma L. Robertson., et al. " Characterization of cerebrospinal fluid biomarkers associated with neurodegenerative diseases in healthy cynomolgus and rhesus macaque monkeys." Alzheimer’s Dement. 2022
  1. Q 1: How does Rhesus Monkey CSF compare to human CSF in biomedical research?

    A: An invaluable resource, the Rhesus Monkey CSF has been of use for biomedical researchers who otherwise find it difficult to recognize the features and mechanisms of drug delivery in the brain concerning diseases like neurodegenerative diseases and CNS disorders.

  2. Q 2: What are the ethical considerations for collecting CSF from Rhesus Monkeys?

    A: Ethical collection of CSF from Rhesus Monkeys requires following strict protocols, including those which put emphasis on welfare, reduce stress or injury to the animals from the procedures, and ensure that the procedures be scientifically justified and should be carried out under veterinary surveillance.

  • Accelerated Our Research
    The use of the Rhesus Monkey CSF product from Creative Biolabs has greatly accelerated our research in the field of neurological pathology. This did contribute to our study in the highest manner and, besides, was consistent.
  • Excellent Customer Support.
    The Rhesus Monkey CSF purchased from Creative Biolabs was a very important part of our studies in the field of drug delivery of the CNS. It has very much been supportive, given the details documented and excellent customer support.

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