Rhesus monkey is an important animal model due to its genetics, physiology and metabolism similarity to human beings. They are well known for their ease of breeding and are widely used in neuroscience, behavioral biology, infectious diseases, reproductive physiology, endocrinology, cardiovascular research, pharmacology, and other fields.
Background of Rhesus Monkey
The Rhesus monkey is also known as Rhesus Macaque or Macaca mulatta. It is a sand-colored primate native to the forest that can be widely distributed in the wild, throughout mainland from Afghanistan to India and Thailand to southern China. It is very bright and flexible, has four limbs, and usually uses them all to move. They are fast crawlers, skilled climbers and proficient swimmers. The Rhesus monkey has a bare pink face, brown and gray hair. Its tail ranges from 8.1 to 9 inches and males are slightly larger than females (males weigh 17 pounds, 21 inches in length, females weigh 12 pounds, and 19 inches in length).
Rhesus Monkey and Derivatives in Research
Rhesus monkeys have a high demand for biomedical research on human health problems, contributing to direct benefits to the development of rabies, smallpox and polio vaccines, understanding of female reproductive cycle and embryonic development, research on propagation embryonic stem cells, and many behavioral discoveries. Determining the Rh factor in human blood involves reactions to the Rhesus monkey's blood, which is the first monkey to be transported into the stratosphere. In immunology, rhesus monkeys are the standard animal model of multiple sclerosis. Additionally, international initiatives to address the medical threat of bioterrorism and to reduce the prevalence of HIV/AIDS depend on scientific access to rhesus monkeys.
The value of rhesus monkeys as in vivo models is limited by the scarcity and cost and impracticability of offspring testing in genetic researches. The uses of primate tissue and cells culture in vitro do reduce the number of animals needed for research. For example, an in vitro rhesus macaque blood-brain barrier (BBB) utilizes autologous microvascular brain endothelial cells and astrocytes are highly correlated with the detection of BBB immune events and prove their potential role in the detection of early events of AIDS neuropathy. Therefore, the use of these tissues in vitro experiments will be a very important complementary method.
Creative Biolabs is a leading provider of quality rhesus monkey tissue samples including whole blood, serum, plasma, primary cells, tissue samples and body fluid for the pharmaceutical, biotechnology, diagnostics, and analytical lab industries. Moreover, we also offer customized services and samples from diseases models to meet your specific needs. Please contact us for more information.