Category:
Non-Human Primate (NHP) related Antibody Products
TBK1 Monoclonal Antibody (A2R5) (NHP-AB249)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
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This product is an antibody that was generated by immunizing mouse against a synthetic peptide corresponding to amino acids 563 - 577 of TBK1 (Human). It is used only in in vitro assays.
Introduction:
Nuclear factor kappa B (NF-KB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-KB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-KB is associated with IKB proteins in the cell cytoplasm, which inhibit NF-KB activity. Phosphorylation of I-KB by IKB kinase (IKK) complex leads to degradation of I-KB and activation of NF-KB. The IKK complex contains IKKa, IKKβ, and IKKK. A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-KB-activating kinase), and T2K. NAK/TBK1 activates IKKβ through direct phosphorylation. NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-kB activation in response to growth factors. NAK/TBK1 functions upstream of NIK and the IKK complex. NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.
Conjugate:
None
Antibody Isotype:
IgG1κ
Applications:
IHC; WB
Host Species:
Mouse
Species Reactivity:
Bovine; Dog; Gibbon; Gorilla; Hamster; Horse; Human; Monkey; Mouse; Pig; Rabbit; Rat
Immunogen:
A synthetic peptide corresponding to amino acids 563 - 577 of TBK1 (Human)
Purification:
Protein G Column
Format:
Liquid
Concentration:
1 mg/mL
Buffer:
PBS, 0.2% gelatin, 0.05% sodium azide.
Storage:
Short term: 4˚C. Long term: Store at -20˚C. Avoid freeze-thaw cycles.
Clone:
A2R5
Clonality:
Monoclonal
Alternative Names:
FLJ11330; NF-kappa-B-activating kinase; NF-kB-activating kinase; serine/threonine protein kinase TBK1; Serine/threonine-protein kinase TBK1; T2K; TANK-binding kinase 1; tbk
Entrez Gene ID:
29110
- TBK1 Monoclonal Antibody (A2R5) (NHP-AB249) Data Sheet: Detailed information. datasheet
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For research use only. Not intended for any clinical use.
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