TBK1 Monoclonal Antibody (A2R5) (NHP-AB249)

• This product is an antibody that was generated by immunizing mouse against a synthetic peptide corresponding to amino acids 563 - 577 of TBK1 (Human). It is used only in in vitro assays.

Detailed Product Description

• Introduction: Nuclear factor kappa B (NF-KB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-KB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-KB is associated with IKB proteins in the cell cytoplasm, which inhibit NF-KB activity. Phosphorylation of I-KB by IKB kinase (IKK) complex leads to degradation of I-KB and activation of NF-KB. The IKK complex contains IKKa, IKKβ, and IKKK. A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-KB-activating kinase), and T2K. NAK/TBK1 activates IKKβ through direct phosphorylation. NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-kB activation in response to growth factors. NAK/TBK1 functions upstream of NIK and the IKK complex. NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.
• Conjugate: None
• Antibody Isotype: IgG1κ
• Applications: IHC; WB

Technical Specifications

• Host Species: Mouse
• Species Reactivity: Bovine; Dog; Gibbon; Gorilla; Hamster; Horse; Human; Monkey; Mouse; Pig; Rabbit; Rat
• Immunogen: A synthetic peptide corresponding to amino acids 563 - 577 of TBK1 (Human)

Product Property

• Purification: Protein G Column
• Format: Liquid
• Concentration: 1 mg/mL
• Buffer: PBS, 0.2% gelatin, 0.05% sodium azide.
• Storage: Short term: 4˚C. Long term: Store at -20˚C. Avoid freeze-thaw cycles.

Target Information

• Clone: A2R5
• Clonality: Monoclonal
• Alternative Names: FLJ11330; NF-kappa-B-activating kinase; NF-kB-activating kinase; serine/threonine protein kinase TBK1; Serine/threonine-protein kinase TBK1; T2K; TANK-binding kinase 1; tbk
• Entrez Gene ID: 29110