TIMP3 Polyclonal Antibody (NHP-AB473)

• This product is an antibody that was generated by immunizing rabbit against recombinant fusion protein containing a sequence corresponding to amino acids 24-211 of human TIMP3 (NP_000353.1). It is used only in in vitro assays.

Detailed Product Description

• Introduction: Tissue inhibitor of metalloproteinase 3 (TIMP3) is a member of the tissue inhibitor of metalloproteinases gene family. It functions to inhibit the activity of matrix metalloproteinases (MMP) which degrade components of the extracellular matrix. TIMP3 is expressed upon mitogenic stimulation. It binds irreversibly to zinc-dependent MMPs and inactivates them by binding to their catalytic zinc cofactor. Other functions of TIMP3 include nervous system development, tissue regeneration, and visual perception. In humans, the gene encoding TIMP3 is located on chromosome 22.
• Conjugate: None
• Antibody Isotype: IgG
• Applications: IF; WB

Technical Specifications

• Host Species: Rabbit
• Species Reactivity: Human; Monkey; Mouse; Rat
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 24-211 of human TIMP3 (NP_000353.1)

Product Property

• Purification: Affinity purification
• Format: Liquid
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Storage: Store at -20⁰C. Avoid freeze-thaw cycles.

Target Information

• Clonality: Polyclonal
• Alternative Names: Metalloproteinase inhibitor 3; MIG-5 protein; Protein MIG-5; TIMP 3; TIMP-3; tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory); Tissue inhibitor of metalloproteinases 3
• Entrez Gene ID: 7078