Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsNeuronal cell adhesion molecule, encoded by the gene NRCAM, is also known as Neuron-glial-related cell adhesion molecule (NRCAM). NRCAM is a member of cell adhesion molecules (CAMs) that belong to the immunoglobulin superfamily, with multiple fibronectin type-III domains and immunoglobulin-like C2-type domains. NRCAM is a 200-220 kDa transmembrane protein with six Ig-like domains and five FnIII repeats in the extracellular region, plus a highly conserved cytoplasmic tail. NRCAM is abundantly expressed in the nervous system but is also detected in a variety of healthy or neoplastic tissues and cell lines including pancreatic cancer, melanoma, renal and colon carcinoma, adrenal gland, placenta, thyroid, and testis.
| Basic Information of NRCAM | |
| Protein Name | Neuronal cell adhesion molecule |
| Gene Name | NRCAM |
| Aliases | Neuronal surface protein Bravo, NgCAM-related cell adhesion molecule |
| Organism | Homo sapiens (Human) |
| UniProt ID | Q92823 |
| TransmNRCAMrane Times | 1 |
| Length (aa) | 1304 |
| Sequence | MQLKIMPKKKRLSAGRVPLILFLCQMISALEVPLDPKLLEDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITEEAVTTVDEAGILPPDVGAGKVQAVNPRISNLTAAAAETYANISWEYEGPEHVNFYVEYGVAGSKEEWRKEIVNGSRSFFGLKGLMPGTAYKVRVGAVGDSGFVSSEDVFETGPAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQYSGKKEKEPAEGNESSEAPSPVNAMNSFV |
As a neuronal cell adhesion molecule, NRCAM is primarily known to be involved in neuron-neuron and neuron-glial adhesion as well as directional signaling during axonal cone growth. Afterward, it is reported to play roles in several cellular processes in the central and peripheral nervous systems, including neurite outgrowth, axonal pathfinding and myelination, fasciculation of nerve fibers, and cell migration. In addition, NRCAM is also detected in non-neural tissues, where it may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Recently, the formation of Ranvier nodes on myelinated axons is also shown to be related to NRCAM expression.
Fig.1 NrCAM inhibits proteolytic cleavage of plexinA1 at the midline. (Derijck, 2010)
This article reveals that NrCAM is an integral component of the Sema3F receptor complex and a new postnatal regulator of dendritic spine density in cortical pyramidal neurons, implicating that NrCAM may contribute to inhibitory/excitatory balance in neocortical circuits.
This article suggests that NrCAM plays a role in addiction-related behaviors through, at least partially, modulation of neural function in the brain and some glutamatergic pathways.
This article indicates that NrCAM has a high expression in the development of the mammalian cochlea. Additionally, it demonstrates that NrCAM may explain neonatal rat inner ear spiral ganglion neurites in vitro.
This article demonstrates that NrCAM is associated with mediolateral retinocollicular axon targeting by regulating RGC branch orientation through a likely mechanism in which ephrinB/EphB phosphorylates NrCAM to modulate linkage to the actin cytoskeleton.
This article reveals that gliomedin, NrCAM, and NF186 can mediate axon-glial contact, which is associated in Na+ channel clustering during development and may be involved in the long-term maintenance of Na+ channels at nodes of Ranvier.
In order to provide high-quality membrane protein preparation service, we have developed a versatile Magic™ membrane protein production platform. Our experienced scientists will do their best to help you find a perfect match in your required formats. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-NRCAM antibody development services.
Creative Biolabs provides first-class membrane protein production service using a variety of strategies. Based on our leading-edge platform, we have successfully produced, purified, stabilized and characterized many challenging membrane protein targets for global customers. If you are interested in the service we can provide, please feel free to contact us for more information.
Reference
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
