ING4-expressing Oncolytic Herpes Simplex Virus 1 (ΔΔICP0), CMV-ING4(Cat#: CyOV-0048XY)
DatasheetThis product is a ING4 expressing oncolytic herpes simplex virus, which is based on HSV-1 with ICP0 deleted. The deletion of ICP0 were attenuated for viral growth, and impaired for viral reactivation when equivalent latent infections were established in vivo. This product can be used in oncolytic virotherapy research and further recombinant HSV construction.
Specifications | |
|---|---|
| Family | Herpesviridae |
| Species | Herpes simplex virus |
| Serotype | Herpes simplex virus 1 |
| Backbone | HSV-1 (ΔΔICP0) |
| Backbone Background | Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. Modified Herpes simplex virus is considered as a potential therapy for cancer and has been extensively clinically tested to assess its oncolytic ability. |
| Gene Modification | ΔΔICP0 |
| Promoter | CMV |
| Transgene | ING4 |
| Type of Transgene | Cytokine |
| Related Target/Protein | Inhibitor of growth family member 4 |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Osteosarcoma |
Transgene | |
|---|---|
| Alternative Names | ING4, my036, p29ING4, inhibitor of growth family member 4 |
| Gene ID | 51147 |
Information | |
|---|---|
| Introduction | Inhibitor of growth protein 4 is a protein that in humans is encoded by the ING4 gene. |
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