IL-4-expressing Oncolytic Herpes Simplex Virus 1 (ΔICP27), IE4/5-IL-4(Cat#: CyOV-0154XY)
DatasheetThis product is a IL-4 expressing oncolytic herpes simplex virus, which is based on HSV-1 with ICP27 deleted. ICP27 is highly cytotoxic probably due to its secondary role of preventing the splicing of pre-mRNAs in favour of translation from the mainly unspliced hepes RNAs. Deletion of ICP27 might produce a safer and less cytotoxic system when combined with other oncolytic-rendered modifications. This product can be used in oncolytic virotherapy research and further recombinant HSV construction.
Specifications | |
|---|---|
| Family | Herpesviridae |
| Species | Herpes simplex virus |
| Serotype | Herpes simplex virus 1 |
| Backbone | HSV-1 (ΔICP27) |
| Backbone Background | Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. Modified Herpes simplex virus is considered as a potential therapy for cancer and has been extensively clinically tested to assess its oncolytic ability. |
| Gene Modification | ΔICP27 |
| Promoter | IE4/5 |
| Transgene | IL-4 |
| Type of Transgene | Cytokine |
| Related Target/Protein | Interleukin 4 |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Tumor |
Transgene | |
|---|---|
| Alternative Names | IL-4, IL4, BCGF-1, BCGF1, BSF-1, BSF1, interleukin 4 |
| Gene ID | 3565 |
Information | |
|---|---|
| Introduction | The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4 in a positive feedback loop. The cell that initially produces IL-4, thus inducing Th2 differentiation, has not been identified, but recent studies suggest that basophils may be the effector cell. It is closely related and has functions similar to Interleukin 13. |
Customer Reviews and Q&As |
|---|
|
There are currently no customer reviews or questions for IL-4-expressing Oncolytic Herpes Simplex Virus 1 (ΔICP27), IE4/5-IL-4 (CyOV-0154XY). Click the button below to contact us or submit your feedback about this product. |
All products and services are for Research Use Only. Not For Clinical Use.
Other products
- mCherry-encoding Oncolytic Herpes Simplex Virus 1 (ΔICP6, ΔΔICP34.5), SV40-mCherry (CAT#: RepOV-0108XY)
- IL-2-expressing Oncolytic Herpes Simplex Virus 2 (ΔRL), SV40-IL-2 (CAT#: CyOV-0391XY)
- IL-10-expressing Oncolytic Herpes Simplex Virus 1 (ΔICP34.5, ΔUNG), IE4/5-IL-10 (CAT#: CyOV-0163XY)
- ING4-expressing Oncolytic Herpes Simplex Virus 2 (ΔICP10PK), CMV-ING4 (CAT#: CyOV-0286XY)
- IL-4-expressing Oncolytic Herpes Simplex Virus 1 (ΔΔICP34.5, ΔΔICP47), hTERT-IL-4 (CAT#: CyOV-0140XY)
- MMP9-expressing Oncolytic Herpes Simplex Virus 2 (ΔRL), hTERT-MMP9 (CAT#: CyOV-0329XY)
- GFP-encoding Oncolytic Herpes Simplex Virus 2 (ΔICP10PK), hTERT-GFP (CAT#: RepOV-0135XY)
- IL-4-expressing Oncolytic Herpes Simplex Virus 2 (ΔRL), hTERT-IL-4 (CAT#: CyOV-0336XY)
PRODUCTS
Online Inquiry