IL-18-expressing Oncolytic Herpes Simplex Virus 1 (ΔICP27), SV40-IL-18(Cat#: CyOV-0222XY)
DatasheetThis product is a IL-18 expressing oncolytic herpes simplex virus, which is based on HSV-1 with ICP27 deleted. ICP27 is highly cytotoxic probably due to its secondary role of preventing the splicing of pre-mRNAs in favour of translation from the mainly unspliced hepes RNAs. Deletion of ICP27 might produce a safer and less cytotoxic system when combined with other oncolytic-rendered modifications. This product can be used in oncolytic virotherapy research and further recombinant HSV construction.
Specifications | |
|---|---|
| Family | Herpesviridae |
| Species | Herpes simplex virus |
| Serotype | Herpes simplex virus 1 |
| Backbone | HSV-1 (ΔICP27) |
| Backbone Background | Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. Modified Herpes simplex virus is considered as a potential therapy for cancer and has been extensively clinically tested to assess its oncolytic ability. |
| Gene Modification | ΔICP27 |
| Promoter | SV40 |
| Transgene | IL-18 |
| Type of Transgene | Cytokine |
| Related Target/Protein | Interleukin 18 |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Tumor |
Transgene | |
|---|---|
| Alternative Names | IGIF, IL-18, IL18, IL-1g, IL1F4, interleukin 18 |
| Gene ID | 3606 |
Information | |
|---|---|
| Introduction | Interleukin-18 (IL18, also known as interferon-gamma inducing factor) is a protein which in humans is encoded by the IL18 gene. The protein encoded by this gene is a proinflammatory cytokine. |
Customer Reviews and Q&As |
|---|
|
There are currently no customer reviews or questions for IL-18-expressing Oncolytic Herpes Simplex Virus 1 (ΔICP27), SV40-IL-18 (CyOV-0222XY). Click the button below to contact us or submit your feedback about this product. |
All products and services are for Research Use Only. Not For Clinical Use.
Other products
- vasculostatin-expressing Oncolytic Herpes Simplex Virus 1 (ΔΔICP0), hTERT-vasculostatin (CAT#: CyOV-0120XY)
- IL-2-expressing Oncolytic Herpes Simplex Virus 1 (ΔΔICP34.5, ΔΔICP47), SV40-IL-2 (CAT#: CyOV-0279XY)
- Dsred-encoding Oncolytic Herpes Simplex Virus 1 (ΔICP34.5, ΔUNG), SV40-Dsred (CAT#: RepOV-0097XY)
- IL-15-expressing Oncolytic Herpes Simplex Virus 1 (ΔΔICP0), CMV-IL-15 (CAT#: CyOV-0053XY)
- MMP9-expressing Oncolytic Herpes Simplex Virus 2 (ΔRL), hTERT-MMP9 (CAT#: CyOV-0329XY)
- lacZ-encoding Oncolytic Herpes Simplex Virus 1 (ΔICP6, ΔΔICP34.5), hTERT-lacZ (CAT#: RepOV-0046XY)
- ING4-expressing Oncolytic Herpes Simplex Virus 2 (ΔICP10PK), hTERT-ING4 (CAT#: CyOV-0314XY)
- IL-12-expressing Oncolytic Herpes Simplex Virus 1 (ΔICP6, ΔΔICP34.5), CMV-IL-12 (CAT#: CyOV-0038XY)
PRODUCTS
Online Inquiry